新型免疫检查点Siglec-15表达与老年结直肠癌预后相关性研究

doi:10.3969/j.issn.1003-9198.2024.07.006

Abstract

Abstract: Objective To examine the expression of Sialic acid-binding immunoglobulin-like lectins(Siglec)-15 in the elderly patients with colorectal cancer(CRC) and to investigate the relationship of the expression of Siglec-15 with the clinical characteristics and the prognosis of CRC. Methods One-step quantitative polymerase chain reaction(qPCR) test was used in 6 fresh CRC samples as well as the corresponding non-cancerous tissue samples and tissue microarrays,and 60 elderly CRC samples and non-cancerous samples were detected by immunohistochemistry analysis. Cox regression and Kaplan-Meier survival analysis were conducted to evaluate the prognostic parameters in this elderly patients with CRC. Results The results of qPCR test and immunohistochemistry analysis showed that the expression of Siglec-15 in CRC tissues was significantly higher than that in paracancerous tissues(P=0.002,0.019,respectively). Moreover, the expression level of Siglec-15 protein in CRC was significantly related to gender(P=0.037), tumor location(P=0.040),lymph node metastasis(P=0.037) and TNM stage(P=0.003). Cox regression and Kaplan-Meier survival analysis showed that high Siglec-15 expression(HR=2.39),tumor differentiation (HR=3.81), distant metastasis(HR=9.53) were the influencing factors in the elderly patients with CRC(P＜0.05). Conclusions Siglec-15 is highly expressed in the CRC tissue, and is correlated with clinicopathological features of CRC. Siglec-15 may serve as a novel prognostic factor for the elderly patients with CRC.

Key words: aged, colorectal cancer, Siglec-15, quantitative polymerase chain reaction, immunohistochemistry, overall survival

CLC Number:

R 735.3

DING Run, XU Li, YANG Junrong, MAO Yuan, ZHU Yidan, LIANG Guodong. Association between the expression of a novel check point Siglec-15 and the prognosis of elderly patients with colorectal cancer[J]. Practical Geriatrics, 2024, 38(7): 669-673.

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Association between the expression of a novel check point Siglec-15 and the prognosis of elderly patients with colorectal cancer

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