血清TIMP-1、M-CSF联合检测对老年病人乙型肝炎后肝硬化早期诊断的价值

doi:10.3969/j.issn.1003-9198.2024.06.015

Abstract

Abstract: Objective To investigate the value of serum tissue inhibitors of metalloproteinase-1 (TIMP-1) and macrophage colony-stimulating factor (M-CSF) levels in the early diagnosis of post-hepatitis B cirrhosis in the elderly patients. Methods A total of 97 elderly patients with post-hepatitis B cirrhosis admitted to our hospital from March 2020 to May 2022 were enrolled as the study group, and 125 elderly patients with hepatitis B during the same period were enrolled as the control group. According to the degree of cirrhosis, the study group was divided into 39 patients with grade A cirrhosis, 33 patients with grade B cirrhosis and 25 patients with grade C cirrhosis. The serum TIMP-1 and M-CSF levels were compared between the two groups and the patients with different grades of cirrhosis, and the correlation between serum TIMP-1 level and serum M-CSF level was analyzed. The influencing factors of cirrhosis in the elderly patients with hepatitis B were analyzed, and the diagnostic value of serum TIMP-1 and M-CSF levels for post-hepatitis B cirrhosis in the elderly patients was analyzed. Results The levels of total bilirubin (TBIL), alpha-fetoprotein (AFP) and prothrombin time (PT) in the study group were higher than those in the control group (P<0.01), and the level of albumin (ALB) was lower than that in the control group (P<0.01). The levels of TIMP-1 and M-CSF in the study group were higher than those in the control group (P<0.01). The serum levels of TIMP-1 and M-CSF in the patients with grade C cirrhosis were highest, followed by grade B and grade A (P<0.05). Serum TIMP-1 level was positively correlated with serum M-CSF level (P< 0.05). Logistic regression analysis showed that TBIL, PT, TIMP-1, M-CSF and ALB were the influencing factors for cirrhosis in the elderly patients with hepatitis B (P<0.05). The area under the curve (AUC) of serum TIMP-1, M-CSF and combination in diagnosing liver cirrhosis in the elderly patients with hepatitis B was 0.821, 0.813 and 0.896, respectively (P<0.05), and the AUC of combination of TIMP-1 and M-CSF was higher (P<0.05). Conclusions Serum TIMP-1 and M-CSF levels have important value in early diagnosis of post-hepatitis B cirrhosis in the elderly patients, and their combination has higher diagnostic value.

Key words: tissue inhibitors of metalloproteinase-1, macrophage colony stimulating factor, aged, hepatitis B, liver cirrhosis, diagnostic value

CLC Number:

R512.62

SHI Hua, HE Zhiwei, GAN Ke. Value of serum TIMP-1 and M-CSF levels in early diagnosis of post-hepatitis B cirrhosis in elderly patients[J]. Practical Geriatrics, 2024, 38(6): 607-611.

References

[1] LEE N Y, SUK K T. The role of the gut microbiome in liver cirrhosis treatment[J]. Int J Mol Sci, 2020,22(1):199.
[2] CHUN H S, CHOE A R, LEE M, et al. Treatment of direct oral anticoagulants in patients with liver cirrhosis and portal vein thrombosis[J]. Clin Mol Hepatol, 2021,27(4):535-552.
[3] MORAN S, LOPEZ-SANCHEZ M, MILKE-GARCIA M, et al. Current approach to treatment of minimal hepatic encephalopathy in patients with liver cirrhosis[J]. World J Gastroenterol, 2021,27(22):3050-3063.
[4] 许雅洁,尤文铮,任万雷,等. 肝活检病理学指标在肝硬化门静脉高压症诊断中的应用[J]. 临床肝胆病杂志,2021,37(12):2935-2938.
[5] FALLOWFIELD J A, JIMENEZ-RAMOS M, ROBERTSON A. Emerging synthetic drugs for the treatment of liver cirrhosis[J]. Expert Opin Emerg Drugs, 2021,26(2):149-163.
[6] 曹海丹,罗晓蓉,吴县斌. 肝纤维化指标、TIMP-1在慢性乙型肝炎纤维化中的诊断效能及与肝硬化的关联性分析[J]. 重庆医学,2021,50(6):991-995.
[7] 李萍,胡蓉,杨启,等. 血清巨噬细胞集落刺激因子在乙肝肝硬化患者中的表达及早期诊断价值[J]. 疑难病杂志,2020,19(1):45-48.
[8] 中华医学会感染病学分会,中华医学会肝病学分会. 慢性乙型肝炎防治指南(2019年版)[J]. 中华肝脏病杂志,2019,27(12):938-961.
[9] 中华医学会肝病学分会. 肝硬化诊治指南[J]. 中华肝脏病杂志,2019,27(11):846-865.
[10] LEE H A, SEO Y S. Current knowledge about biomarkers of acute kidney injury in liver cirrhosis[J]. Clin Mol Hepatol, 2022,28(1):31-46.
[11] XU X Y, DING H G, LI W G, et al. Chinese guidelines on the management of liver cirrhosis (abbreviated version)[J]. World J Gastroenterol, 2020,26(45):7088-7103.
[12] 蒙增萍,翟丽琼,李燚,等. 肝硬化患者Child-Pugh分级与凝血4项、D-二聚体的关系[J]. 贵州医科大学学报,2022,47(1):66-71,78.
[13] YUAN S, WEI C, LIU G, et al. Sorafenib attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis via HIF-1alpha/SLC7A11 pathway[J]. Cell Prolif, 2022,55(1):13158.
[14] ZDANOWICZ K, KOWALCZUK-KRYSTON M, OLANSKI W, et al. Increase in serum MMP-9 and TIMP-1 concentrations during alcohol intoxication in adolescents-a preliminary study[J]. Biomolecules, 2022,12(5):710.
[15] EGUCHI A, IWASA M, SUGIMOTO R, et al. Complement complex 1 subunit q-mediated hepatic stellate cell activation with connective tissue growth factor elevation is a prognostic factor for survival in rat and human chronic liver diseases[J]. Hepatol Commun, 2022,6(12):3515-3527.
[16] 向焰,向婷,张正娟,等. HBV感染者血清M-CSF、DNMT1和PD-1水平与疾病进展的相关性[J]. 国际检验医学杂志,2022,43(16):1980-1983.
[17] KARMACHARYA M B, HADA B, PARK S R, et al. Granulocyte-macrophage colony-stimulating factor (GM-CSF) shows therapeutic effect on dimethylnitrosamine (DMN)-induced liver fibrosis in rats[J]. PLoS One, 2022,17(9):274126.
[18] 师秀雪,滑少华,陈菲. 腹部超声联合血清巨噬细胞集落刺激因子水平检测对慢性乙型肝炎肝纤维化程度的诊断价值[J]. 郑州大学学报(医学版),2021,56(3):426-431.
[19] 王殷秋,曹雯君,郜玉峰,等. M-CSF血清水平与慢性HBV感染患者肝脏纤维化程度的相关性研究[J]. 安徽医科大学学报,2018,53(4):614-619.
[20] 杨建波,张欢,马欢,等. 乙肝肝硬化与慢性乙肝患者生化指标的比较[J]. 中国热带医学,2022,22(2):129-133.

Value of serum TIMP-1 and M-CSF levels in early diagnosis of post-hepatitis B cirrhosis in elderly patients

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Recommended 10

[1]	LI Jiang, QIU Yan, WANG Ting, WANG Dan, YU Yifan, PU Lingli, BU Ling. Correlation between preoperative SII/ALB and clinicopathologic features in elderly patients with lung adenocarcinoma [J]. Practical Geriatrics, 2024, 38(9): 893-896.
[2]	DAI Jing, CUI Yan. Correlation between glycosylated hemoglobin variability and cognitive dysfunction in elderly patients with type 2 diabetes mellitus [J]. Practical Geriatrics, 2024, 38(9): 931-935.
[3]	ZHENG Hong, QI Zhenbo, XU Peng, XU Jie, YU Xinyu, ZANG Yanan, ZHANG Zhaoyan. Effects of hypnotics on cognition function and daytime sleepiness in the elderly [J]. Practical Geriatrics, 2024, 38(9): 936-939.
[4]	ZHANG Xingxing, ZHANG Haiyang, HE Xiaojing, LU Xiang. Investigation on the relationship between different physical indexes and the risk of diabetes mellitus in the elderly [J]. Practical Geriatrics, 2024, 38(9): 940-943.
[5]	NI Hongyan, CHEN Yun, ZHANG Qibing, MA Yiming, XIE Chenglan. Effects of electroacupuncture on cognitive function and inflammatory factors in elderly patients undergoing lower limb orthopedic surgery during the perioperative period [J]. Practical Geriatrics, 2024, 38(9): 944-947.
[6]	LI Xiaomin, LI Xiaolin, LI Jie, WU Lei, HAO Ranran. Efficiency influencing factors of transanal double-balloon enteroscopy in elderly patients [J]. Practical Geriatrics, 2024, 38(9): 958-961.
[7]	CAI Huicui, CHEN Yan, WANG Yan, YE Jinjun, ZHU Yuying. Effects of diversified health education model with simple respiratory function exercise on cancer-related fatigue and compliance behavior in elderly patients with lung cancer receiving radiotherapy [J]. Practical Geriatrics, 2024, 38(9): 968-972.
[8]	WANG Xiaojiao, WANG Ning, CUI Hong, YE Tong, WANG Xiaoming. Influence of exercise rehabilitation in elderly patients with mild to moderate chronic heart failure [J]. Practical Geriatrics, 2024, 38(8): 775-778.
[9]	SHEN Chenjun, WANG Xiaoqing, TANG Degang, NING Ping. Correlation between standardized uric acid and renal function in elderly patients with chronic kidney disease aged 90 and over [J]. Practical Geriatrics, 2024, 38(8): 779-782.
[10]	HAO Shijie, ZOU Jianpeng, WEI Chen, LIU Qingjiang. Effect of comprehensive respiratory training on hypokinetic dysarthria in elderly patients with Parkinson’s disease [J]. Practical Geriatrics, 2024, 38(8): 783-787.
[11]	XIANG Chao, LUO Caidong. Analysis of the diagnostic value of T wave change of avL lead for the degree of coronary artery stenosis in elderly patients with coronary heart disease [J]. Practical Geriatrics, 2024, 38(8): 788-791.
[12]	LI Huiying, CAI Lili, ZHU Qiwei. Predictive value of plasma N-terminal pro-brain natriuretic peptide for prognosis in patients aged ≥80 years old with left ventricular hypertrophy [J]. Practical Geriatrics, 2024, 38(8): 797-801.
[13]	WANG Xinping, XIE Baimei, WEI Guo, YE Xiaoli, ZHAO Yayun, TAN Xiaotian. Expression levels and clinical significance of serum S100A9 and sCD163 in elderly patients with idiopathic interstitial pneumonia [J]. Practical Geriatrics, 2024, 38(8): 802-807.
[14]	LIU Meijuan, WANG Ning, WANG Dong, LU Fangzhou, LIU Juan. Effect of low-dose lidocaine combined with propofol on motor evoked potential in elderly patients undergoing intracranial tumor resection [J]. Practical Geriatrics, 2024, 38(8): 808-811.
[15]	LI Jingbing, WANG Huijun, WANG Shaoying, ZHAO Can, WANG Lidi, CAO Yujiao. Impacts of pentoxifylline combined with lipoic acid intervention on physical function and quality of life in elderly patients with frailty syndrome [J]. Practical Geriatrics, 2024, 38(8): 812-815.