血清和尿CN1在老年糖尿病肾病中的诊断价值分析

doi:10.3969/j.issn.1003-9198.2023.08.019

Abstract

Abstract: Objective To study the clinical value of serum and urine carnosine dipeptidase 1 (CN1) in the diagnosis of diabetic nephropathy (DN) in the elderly. Methods A total of 168 elderly patients with type 2 diabetes mellitus (T2DM) in our hospital were enrolled and divided into control group (n=46) and DN group (n=122) according to whether the level of urinary albumin creatinine ratio (UACR) was≥30 mg/g. The serum and urine levels of CN1 and the serum levels of the clinical biochemical indicators were compared between the two groups, and were analyzed by Pearson correlation. Multivariate Logistic regression analysis was used to analyze the influencing factors of DN. The diagnostic value of each index for DN was analyzed by the receiver operating characteristic (ROC) curve. Results Compared with the control group, the level of estimated glomerular filtration rate (eGFR) was lower, while the UACR, the serum levels of creatinine, urea nitrogen, uric acid and cystatin C, and the serum and urine levels of CN1 were significantly higher in the DN group (all P<0.05). Serum and urine levels of CN1 were significantly positively correlated with UACR, serum levels of creatinine and urea nitrogen, and significantly negatively correlated with eGFR (all P<0.05). The levels of eGFR, cystatin C, serum and urine CN1 were the independent influencing factors of DN. The area under the ROC curve (AUC) of eGFR, cystatin C, serum CN1, urine CN1 and combined detection for the diagnosis of DN were 0.851, 0.760, 0.838, 0.849 and 0.944, respectively. The AUC of combined detection was significantly better than that of single indicator (P<0.05). Conclusions The increased serum and urinary levels of CN1 in diabetic patients are independent risk factors affecting the occurrence of DN in the elderly. Combined detection of eGFR, cystatin C, serum and urinary CN1 has high diagnostic value for DN.

Key words: aged, diabetic nephropathy, carnosine dipeptidase 1, risk factor, diagnostic value

CLC Number:

R 587.2

HE Ye-nan, SUN Ming-xia, SONG Dan-dan, ZHAO Xiao-lan. Diagnostic value of serum and urine CN1 for diabetic nephropathy in elderly patients[J]. Practical Geriatrics, 2023, 37(8): 834-838.

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Diagnostic value of serum and urine CN1 for diabetic nephropathy in elderly patients

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