纤维蛋白原与白蛋白比值对老年疑似冠心病病人冠脉病变程度的预测价值

doi:10.3969/j.issn.1003-9198.2023.08.013

Abstract

Abstract: Objective To investigate the value of fibrinogen to albumin ratio(FAR) in predicting the severity of coronary artery lesions in the elderly patients with suspected coronary artery disease(CAD). Methods Five hundred and thirty-three elderly patients with suspected CAD who underwent coronary angiography for the first time in Hebei General Hospital from January 2018 to May 2022 were selected. All patients were divided into the group with severe coronary lesions(Gensini score>48) and the group with mild to moderate lesions(Gensini score≤48) according to the Gensini score. Receiver operating characteristic (ROC) curve was used to get the cut-off point of FAR to predict severe coronary artery lesions in the elderly patients with suspected CAD. Spearman correlation analysis was used to assess the correlation between FAR and Gensini score. The risk factors for severe coronary artery lesions were analyzed by multivariate Logistic regression. Results The best cut-off value of FAR to predict severe coronary lesions in the elderly patients with suspected CAD was 0.076, with the area under the curve(AUC) of 0.710, sensitivity of 61.1%, specificity of 76.2%(P<0.001). There was a positive correlation between FAR and Gensini score(r=0.440, P<0.001). Multivariate Logistic stepwise regression analysis showed that FAR >0.076, high levels of apolipoprotein B, lipoprotein(a), and a history of diabetes were risk factors of severe CAD (P<0.05), whereas high levels of high density cholesterol(HDL-C) and left ventricular ejection fractions (LVEF) were protective factors of severe CAD (P<0.05) in the elderly patients with suspected CAD. Conclusions There is a significant correlation between FAR and the degree of CAD in the elderly patients with suspected CAD, and FAR>0.076 is an independent risk factor for severe CAD.

Key words: fibrinogen to albumin ratio, severity of coronary artery lesions, aged, predictive value

CLC Number:

R 543.31

WANG Zhao-yang, ZHAO Li-na, LIANG Hao, CHEN Shu-xia, GU Jian. Predictive value of fibrinogen to albumin ratio on the severity of coronary lesions in elderly patients with suspected coronary artery disease[J]. Practical Geriatrics, 2023, 37(8): 806-810.

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Predictive value of fibrinogen to albumin ratio on the severity of coronary lesions in elderly patients with suspected coronary artery disease

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