调强放疗的不同剂量分割模式对老年食管鳞癌的临床疗效观察

doi:10.3969/j.issn.1003-9198.2022.10.009

Abstract

Abstract: Objective To investigate the clinical effects of different dose-fractionations of intensity-modulated radiotherapy for esophageal squamous cell carcinomas in the elderly patients, and to explore the optimal dose-fractionation. Methods A total of 102 elderly patients with esophageal squamous cell carcinoma who received radiotherapy in our hospital from October 2010 to February 2015 were enrolled in this study. According to different dose-fractionations model, all cases were divided into three groups, group A receiving a single radiotherapy dose of 2.0 Gy, 25-30 times in total, with total dose of 50-60 Gy, with a biologically effective dose (BED) of 60-72 Gy; Group B receiving a single radiotherapy dose of 2.2 Gy, 23-27 times in total, with total dose of 50.6-59.4 Gy, with a BED of 61.7-72.5 Gy; Group C receiving a single radiotherapy dose of 2.5 Gy, 19-23 times in total, with total dose of 47.5-57.5 Gy, with a BED of 59.4-71.9 Gy. The adverse reaction rate, local control rate and survival rate of the three groups were analyzed. Results The total effective rate in group A, group B and group C was 82.8%(24/29), 91.7%(44/48) and 96.0%(24/25), resprectively, with no statistically significant difference (P>0.05). There were no significant differences in local control rate for 1-3 years and the survival rates for 1-2 years among the three groups(P>0.05). The 3-year survival rate in group A, group B and group C was 17.2%, 31.3%, 16.0%, respectively, with statistically significant difference (P=0.049). Conclusions Hypofractionated radiotherapy mode (2.2 Gy) in intensity-modulated radiotherapy is an optional radiotherapy scheme for advanced esophageal squamous cell carcinoma in the elderly, but the optimal mode still needs further clinical research.

Key words: esophageal squamous cell carcinomas, aged, hypofractionated radiotherapy

CLC Number:

R735.1

LI Xiao-long, LIU Qiu-fang, LI Liang, WANG Tian-chang, WANG Feng-gang, WU Lei, DAI Zhen, LU Wan-lin. Clinical observation of different dose-fractionations of intensity-modulated radiotherapy for elderly patients with esophageal squamous cell carcinomas[J]. Practical Geriatrics, 2022, 36(10): 1010-1014.

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Clinical observation of different dose-fractionations of intensity-modulated radiotherapy for elderly patients with esophageal squamous cell carcinomas

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