Abstract: Objective To study the relationship between platelet-to-lymphocyte ratio (PLR) and left ventricular diastolic function in the elderly patients with heart failure with preserved ejection fraction (HFpEF). Methods A total of 53 elderly patients with HFpEF were enrolled. According to the transmitral flow velocities to mitral annulus tissue velocities ratio in early diastole (E/e'), the patients were divided into low E/e' group (E/e'＜8), middle E/e' group (8≤E/e'≤14) and high E/e' group (E/e'＞14). The clinical characteristics, biochemical indicators, cardiac ultrasound and other related indicators of these patients were detected and compared among the three groups. And the relationship between PLR and E/e' was analyzed. Results There were significant differences in age, lymphocyte count (LY) and PLR among the three groups (P＜0.05), but there were no significant differences in other indicators among the three groups (P＞0.05). Spearman correlation analysis showed that PLR was negatively correlated to E/e' (P＜0.05); LY and age were positively correlated to E/e' (P＜0.05). Left ventricular end-diastolic diameter and left ventricular end-systolic diameter had positive correlation with PLR (P＜0.05). Simple linear regression analysis showed that PLR showed significant effect on E/e' (F=12.361, P＝0.001), and the regression equation can be obtained as E/e'=18.145-0.030×PLR. Multiple linear regression analysis showed that PLR was an independent factor influencing E/e' (b=-0.025, t=-2.401, P=0.020). Conclusions PLR is closely related to the left ventricular diastolic function in the elderly patients with HFpEF.

Key words: aged, heart failure with preserved ejection fraction, platelet-to-lymphocyte ratio, left ventricular diastolic function