Abstract: Objective To evaluate the safety and efficacy of minimally invasive percutaneous nephrolithotomy(mPCNL) in the treatment of the elderly patients with kidney stones. Methods The clinical data of the patients with kidney stones treated with mPCNL from 2017 to 2019 were collected, and the patients were divided into the young group (<60 years) and the elderly group (≥60 years).The differences in stone diameter, operation time, retention time of nephrostomy, stone clearance rate, length of hospital stay, postoperative complications between the two groups were analyzed. Results A total of 310 patients were enrolled, including 168 cases in the young group and 142 cases in the elderly group. There were no significant differences in urinary culture, stone size, operation time, retention time of nephrostomy and length of hospital stay between the two groups (P>0.05).There were statistically significant differences in the prevalance rate of hypertension, American Soctety of Anesthesiologists (ASA) degree and the incidence rate of fever after operaion (P<0.05). Conclusions mPCNL for the treatment of kidney stones in the elderly shows good efficacy and safety, with good clinical application value.

Key words: minimally invasive percutaneous nephrolithotomy, kidney stones, complications, efficacy, aged