Abstract: Objective To investigate the epidemiological status of cognitive function, depression and medication compliance of the elderly patients with human immunodeficiency virus (HIV) in Hunan Province and to conduct correlation analysis. Methods A total of 252 people infected with HIV aged ≥60 years old were selected by the random sampling method. The general social information questionnaire, the Montreal Cognitive Assessment Scale (MoCA), the Five Geriatric Depression Scale (GDS-5), and the Morisky Medication compliance (MMAS-8) were used to investigate the patients' cognitive function, depression and medication adherence status, respectively. Results The scores of MoCA, GDS-5 and MMAS-8 were 18.16±5.57,0.51±1.15 and 7.56±0.82,respectively. The proportion of cognitive abnormalities was 89.2%; The proportion of depressive symptoms was 12.7%; The high compliance rate of taking medicine was 81.97%, the middle compliance rate was 16.26%, and the low compliance rate was 2.77%. The dimensions with greatest decline in cognitive function were memory, visual space and executive ability. Depression was negatively correlated with medication compliance score (r=-0.243, P<0.01), and MoCA score was positively correlated with depression score (r=0.155, P<0.05), but the correlation between cognitive function and medication compliance was not statistically significant (r=0.055, P>0.05). Conclusions The cognitive function is relatively low in the patients infected with HIV, but the depressive symptoms are mild, and medication compliance does not meet 95% as the target. The depression is positively related to cognitive function and negatively related to medication compliance.

Key words: aged, human immunodeficiency virus, cognitive function, correlation analysis