甲状旁腺激素辅助老年骨质疏松性股骨转子间骨折术后愈合效果研究

doi:10.3969/j.issn.1003-9198.2021.07.011

Abstract

Abstract: Objective To investigate the clinical efficacy of parathyroid hormone assisted in the elderly patients with osteoporotic fracture in the course of healing. Methods A total of 60 patients with osteoporotic fracture admitted to our hospital from January 2019 to December 2019 were prospectively selected and randomly divided into two groups, with 30 cases in each group. The control group was treated with conservative osteoporosis therapy, and the experimental group were treated with intermittent adjuvant subcutaneous injection of parathyroid hormone 20 μg /d on the basis of the treatment of the control group. The recovery of fracture, bone metabolism index and pain degree and joint function were observed and compared. Results After the operation, the pain of joint was significantly alleviated, the excellent rate of hip Harris score was increased, the fracture healing time was shorter, the levels of bone mineral density (BMD) and bone gla protein (BGP) were increased,while the levels of alkaline phosphatase and β-CrOSSlaps(β-CTX) were decreased significantly in two groups(P<0.05),especially in the experimental group(P<0.05). Conclusions Parathyroid hormone has a significant effect on postoperative healing of osteoporotic fracture, which can reduce postoperative pain and promote fracture healing and joint function recovery.

Key words: parathyroid hormone, osteoporotic fracture, aged, postoperative healing, bone metabolism index

CLC Number:

R 687.3

SONG Yao-dong. Clinical efficacy of parathyroid hormone in the treatment of elderly patients with osteoporotic intertrochanteric fracture[J]. Practical Geriatrics, 2021, 35(7): 705-708.

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Clinical efficacy of parathyroid hormone in the treatment of elderly patients with osteoporotic intertrochanteric fracture

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