利拉鲁肽治疗老年早期2型糖尿病肾病的临床分析

doi:10.3969/j.issn.1003-9198.2021.06.008

Abstract

Abstract: Objective To observe the efficacy of liraglutide in the elderly patients with early type 2 diabetic nephropathy and the effects on glucolipid metabolism, 24 h microalbuminuria and renal function. Methods A total of 124 elderly patients with early type 2 diabetic nephropathy from December 24, 2019 to November 13, 2020 in West China Hospital, Sichuan University were enrolled and divided into observation group and control group according to the random number table method, with 62 cases in each group. The patients in control group received routine treatment for hyperlipoidemia and hypertension, and insulin injection or oral administration of hypoglycemic drugs. The patients in observation group received liraglutide on the basis of control group. The total effective rate 8 weeks after treatment, as well as glucose metabolism indexes [fasting plasma glucose (FPG), postprandial 2 h blood glucose (2hPG), glycosylated hemoglobin (HbA1c), fasting insulin (FINS)], lipid metabolism indicators [total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C)], 24 h microalbuminuria and renal function indicators [Cystatin C (CysC), random urine albumin/creatinine ratio (UACR)] before treatment and 8 weeks after treatment were compared between the two groups. Results After 8 weeks of treatment, the total effective rate in observation group was higher than that in control group (P<0.01). The levels of FPG, 2hPG, HbA1c, FINS, TC, TG, LDL-C, 24h microalbuminuria, CysC and UACR in the two groups were lower than those before treatment, and the level of HDL-C was higher than that before treatment, especially in observation group (P<0.01). Conclusions Liraglutide shows an exact efficacy in the treatment of early type 2 diabetic nephropathy in the elderly. And it can effectively improve the glucolipid metabolism and protect the renal function, with a certain clinical application value.

Key words: liraglutide, type 2 diabetes mellitus, diabetic nephropathy, glucolipid metabolism, renal function, aged

CLC Number:

R 587.2

RUAN Yi, LI Jing, HUANG Xiao-rong. Clinical analysis of liraglutide in the treatment of early type 2 diabetic nephropathy in elderly[J]. Practical Geriatrics, 2021, 35(6): 568-571.

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Clinical analysis of liraglutide in the treatment of early type 2 diabetic nephropathy in elderly

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