Abstract: Objective To investigate the clinical characteristics of the elderly patients with gastroesophageal reflux disease(GERD) and to explore the status of anxiety and depression in the patients with GERD and its influencing factors. Methods From March 2018 to August 2019,a total of 681 patients with GERD in outpatient and inpatient departments underwent questionaire survey. Self-rating anxiety scale(SAS) and self-rating depression scale(SDS) were used to evaluate the anxiety and depression of the GERD patients. The clinical characteristics of the elderly group(≥60 years old) and the non-elderly group were compared and analyzed, and the risk factors of anxiety and depression in the elderly GERD patients were analyzed. Results The proportion of reflux esophagitis (RE) in the elderly group was higher than that in the non-elderly group (31.4% vs 23.3 %,P<0.05), and the proportion of typical symptoms (reflux,heartburn) was lower,the proportion of atypical symptoms was higher than that in the non-elderly group(P<0.05), including chest pain, abdominal pain, burning sensation in the upper abdomen, swallowing discomfort.In the elderly group, the proportion of patients with extraesophageal symptoms was higher than that in the non-elderly group (49.6%vs 38.1%,P<0.05), and the incidence rate of anxiety and depression was higher than that in the non-elderly group (44.3% vs 34.8%,P<0.05). Multivariate Logistic regression analysis showed that female, non-erosive gastrooesophageal reflux disease(NERD) and extraesophageal symptoms were risk factors for anxiety and depression in the elderly GERD patients. Conclusions The elderly GERD patients are more likely to have RE, atypical symptoms and extraesophageal symptoms, and the incidence rate of anxiety and depression is higher than that of non-elderly GERD patients. Female, NERD and extraesophageal symptoms are risk factors for anxiety and depression in the elderly GERD patients.

Key words: aged, gastroesophageal reflux disease, clinical characteristic, anxiety and depression