Abstract: Objective To evaluate the efficacy and safety of endovascular mechanical thrombectomy in the elderly patients with anterior circulation acute ischemic stroke. Methods A retrospective analysis of the patients who underwent the endovascular mechanical thrombectomy for acute ischemic stroke from February 2018 to September 2019 was conducted, and finally 90 cases were included.Thirty-eight patients aged ≥80 years were enrolled in the elderly group, and 52 patients aged <80 years were enrolled in the young age group.The baseline data and perioperative data of all patients were collected. The efficacy was analyzed by comparing modified Thrombolysis in Cerebral Infarction (mTICI) scores, and the scores of National Institutes of Health Stroke Scale(NIHSS), the Modified Rankin Scale(mRS). The safety was analyzed by comparing the risk of symptomatic cerebral hemorrhage and mortality. Multivariate Logistic regression analysis was used to analyze the independent influencing factors of the prognosis. Results There were significant differences in the time from puncture to vascular recanalization and 90-d prognosis between the two groups. Multivariate Logistic regression analysis showed that complete recanalization(mTICI3) was the positive factor for the prognosis. Conclusions Endovascular mechanical thrombectomy is effective for the elderly patients with acute ischemic stroke in the anterior circulation. In the case of complete recanalization of mTICI3, the elderly patients can also achieve good prognosis.

Key words: acute ischemic stroke, aged, mechanical thrombectomy, prognosis