Practical Geriatrics ›› 2026, Vol. 40 ›› Issue (2): 201-205.doi: 10.3969/j.issn.1003-9198.2026.02.019
Previous Articles Next Articles
HU Yue, TANG Xiaojia, XU Jun
Received:2025-07-12
Online:2026-02-20
Published:2026-02-27
Contact:
XU Jun, Email: neurojun@126.com
CLC Number:
HU Yue, TANG Xiaojia, XU Jun. Research progress of Parkinson’s disease-related rapid eye movement sleep behavior disorder[J]. Practical Geriatrics, 2026, 40(2): 201-205.
| [1] SCHÄFER C, BRILL A K, WULF M A, et al. REM-sleep-behavior disorder-more than a simple parasomnia[J]. Praxis, 2025, 114(2):51-55. [2] CARVALHO D Z, SCHÖNWALD S V, SCHUMACHER-SCHUH A F, et al. Overnight S100B in Parkinson’s disease: a glimpse into sleep-related neuroinflammation[J]. Neurosci Lett, 2015, 608: 57-63. [3] GALBIATI A, VERGA L, GIORA E, et al. The risk of neurodegeneration in REM sleep behavior disorder:a systematic review and meta-analysis of longitudinal studies[J]. Sleep Med Rev, 2019, 43: 37-46. [4] FERINI-STRAMBI L, FASIELLO E, SFORZA M, et al. Neuropsychological,electrophysiological, and neuroimaging biomarkers for REM behavior disorder[J]. Expert Rev Neurother, 2019, 19(11): 1069-1087. [5] CHEN Y, XIE W Y, XIA D, et al. GBA-AAV mitigates sleep disruptions and motor deficits in mice with REM sleep behavior disorder[J]. NPJ Parkinsons Dis, 2024, 10(1): 142. [6] SCHENCK C H, BUNDLIE S R, MAHOWALD M W. Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder[J]. Neurology, 1996, 46(2): 388-393. [7] HABA-RUBIO J, FRAUSCHER B, MARQUES-VIDAL P, et al. Prevalence and determinants of rapid eye movement sleep behavior disorder in the general population[J]. Sleep, 2018, 41(2): zsx197. [8] RODRIGUEZ C L, JAIMCHARIYATAM N, BUDUR K. Rapid eye movement sleep behavior disorder: a review of the literature and update on current concepts[J]. Chest, 2017, 152(3): 650-662. [9] MATAR E, MCCARTER S J, ST LOUIS E K, et al. Current concepts and controversies in the management of REM sleep behavior disorder[J]. Neurotherapeutics, 2021, 18(1): 107-123. [10] 魏蔚, 邢佳, 王一帆, 等. 2022版《美国睡眠医学会临床实践指南: 快速眼动睡眠行为障碍的管理》解读[J]. 河北医科大学学报, 2023, 44(9): 993-997, 1042. [11] LIU Y, NIU L, LIU X, et al. Recent progress in non-motor features of Parkinson’s disease with a focus on circadian rhythm dysregulation[J]. Neurosci Bull, 2021, 37(7): 1010-1024. [12] SCHENCK C H, BOEVE B F, MAHOWALD M W. Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series[J]. Sleep Med, 2013, 14(8): 744-748. [13] TERZAGHI M, TOSCANO G, CASONI F, et al. Assessment of cognitive profile as a prodromal marker of the evolution of rapid eye movement sleep behavior disorder[J]. Sleep, 2019, 42(8): zsz103. [14] VIDENOVIC A, MARLIN C, ALIBIGLOU L, et al. Increased REM sleep without atonia in Parkinson disease with freezing of gait[J]. Neurology, 2013, 81(12): 1030-1035. [15] CHEN T Z, XU G J, ZHOU G A, et al. Postural sway in idiopathic rapid eye movement sleep behavior disorder: a potential marker of prodromal Parkinson’s disease[J]. Brain Res, 2014, 1559: 26-32. [16] JIN H, ZHANG J R, SHEN Y, et al. Clinical significance of REM sleep behavior disorders and other non-motor symptoms of parkinsonism[J]. Neurosci Bull, 2017, 33(5): 576-584. [17] BOEVE B F. REM sleep behavior disorder: updated review of the core features, the REM sleep behavior disorder-neurodegenerative disease association, evolving concepts, controversies, and future directions[J]. Ann N Y Acad Sci, 2010, 1184: 15-54. [18] ZHANG X, CHAI C, GHASSABAN K, et al. Assessing brain iron and volume of subcortical nuclei in idiopathic rapid eye movement sleep behavior disorder[J]. Sleep, 2021, 44(10): zsab131. [19] RADWAN B, LIU H, CHAUDHURY D. The role of dopamine in mood disorders and the associated changes in circadian rhythms and sleep-wake cycle[J]. Brain Res, 2019, 1713: 42-51. [20] POLITIS M, PICCINI P, PAVESE N, et al. Evidence of dopamine dysfunction in the hypothalamus of patients with Parkinson’s disease: an in vivo 11C-raclopride PET study[J]. Exp Neurol, 2008, 214(1): 112-116. [21] TARGA A D S, RODRIGUES L S, NOSEDA A C D, et al. Unraveling a new circuitry for sleep regulation in Parkinson’s disease[J]. Neuropharmacology, 2016, 108: 161-171. [22] YUAN T, ZUO Z, XU J. Neuroanatomical localization of rapid eye movement sleep behavior disorder in human brain using lesion network mapping[J]. Korean J Radiol, 2023, 24(3): 247-258. [23] SALSONE M, CERASA A, ARABIA G, et al. Reduced thalamic volume in Parkinson disease with REM sleep behavior disorder: volumetric study[J]. Parkinsonism Relat Disord, 2014, 20(9): 1004-1008. [24] BOEVE B F, SILBER M H, SAPER C B, et al. Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease[J]. Brain, 2007, 130(Pt 11): 2770-2788. [25] ZHANG H, GU Z, YAO C, et al. Risk factors for possible REM sleep behavior disorders:a community-based study in Beijing[J]. Neurology, 2020, 95(16): e2214-e2224. [26] LUPPI P H, CLÉMENT O, VALENCIA GARCIA S, et al. New aspects in the pathophysiology of rapid eye movement sleep behavior disorder: the potential role of glutamate, gamma-aminobutyric acid, and glycine[J]. Sleep Med, 2013, 14(8): 714-718. [27] BRINK-KJÆR A, CESARI M, SIXEL-DÖRING F, et al. Arousal characteristics in patients with Parkinson’s disease and isolated rapid eye movement sleep behavior disorder[J]. Sleep, 2021, 44(12): zsab167. [28] PEREZ-LLORET S, CHEVALIER G, BORDET S, et al. The genetic basis of probable REM sleep behavior disorder in Parkinson’s disease[J]. Brain Sci, 2023, 13(8):1146. [29] DI FOLCO C, COURONNÉ R, ARNULF I, et al. Charting disease trajectories from isolated REM sleep behavior disorder to Parkinson’s disease[J]. Mov Disord, 2024, 39(1): 64-75. [30] GAN-OR Z, GIRARD S L, NOREAU A, et al. Parkinson’s disease genetic loci in rapid eye movement sleep behavior disorder[J]. J Mol Neurosci, 2015, 56(3): 617-622. [31] FERNÁNDEZ-SANTIAGO R, IRANZO A, GAIG C, et al. MAPT association with REM sleep behavior disorder[J]. Neurol Genet, 2017, 3(1): e131. [32] HOWELL M, AVIDAN A Y, FOLDVARY-SCHAEFER N, et al. Management of REM sleep behavior disorder: an American Academy of Sleep Medicine clinical practice guideline[J]. J Clin Sleep Med, 2023, 19(4): 759-768. [33] CESARI M, HEIDBREDER A, ST LOUIS E K, et al. Video-polysomnography procedures for diagnosis of rapid eye movement sleep behavior disorder (RBD) and the identification of its prodromal stages: guidelines from the International RBD Study Group[J]. Sleep, 2022, 45(3): zsab257. [34] TRAUER J M, QIAN M Y, DOYLE J S, et al. Cognitive behavioral therapy for chronic insomnia: a systematic review and meta-analysis[J]. Ann Intern Med, 2015, 163(3): 191-204. [35] CAVALLOTTI S, STEIN H C, SAVARESE M, et al. Aggressiveness in the dreams of drug-naïve and clonazepam-treated patients with isolated REM sleep behavior disorder[J]. Sleep Med, 2022, 92: 19-23. [36] SOBREIRA-NETO M A, STELZER F G, GITAÍ L L G, et al. REM sleep behavior disorder: update on diagnosis and management[J]. Arq Neuropsiquiatr, 2023, 81(12): 1179-1194. [37] BLIWISE D L, TROTTI L M, GREER S A, et al. Phasic muscle activity in sleep and clinical features of Parkinson disease[J]. Ann Neurol, 2010, 68(3): 353-359. |
| [1] | SUN Yang, GUO Ying. Research progress on drug targets for Alzheimer’s disease-related cognitive impairment [J]. Practical Geriatrics, 2026, 40(2): 116-120. |
| [2] | LI Jiachun, YAN Li, LIU Jiye, SUN Weimin. Research progress on drug targets for sleep disorders in the elderly [J]. Practical Geriatrics, 2026, 40(2): 121-125. |
| [3] | WANG Jinfeng, SONG Jiao, JIANG Yangyang, YANG Xue, LI Ying. Association between sleep quality and depressive symptoms in residents with cognitive impairment residing in nursing homes [J]. Practical Geriatrics, 2026, 40(1): 16-20. |
| [4] | E Yuqian, CAO Wenping, ZHAO Chunsheng, CAO Shengwu. Study on the safety of trajectory for deep brain stimulation in elderly patients [J]. Practical Geriatrics, 2025, 39(7): 727-731. |
| [5] | WANG Qi, WANG Zhe, WANG Yuehui. Research progress on inflammation and sleep disorders [J]. Practical Geriatrics, 2025, 39(6): 543-546. |
| [6] | ZHOU Xiang, XIANG Xiaoping. Effects of different-intensity phototherapy on sleep quality in elderly patients with Parkinson’s disease and insomnia [J]. Practical Geriatrics, 2025, 39(4): 401-405. |
| [7] | WU Ziwen, ZHANG Li. Epidemiological characteristics of chronic neurological diseases in the elderly [J]. Practical Geriatrics, 2025, 39(3): 223-227. |
| [8] | WANG Guanqun, WANG Xinping, YUAN Yongsheng. Research advances of artificial intelligence in the treatment of Parkinson’s disease [J]. Practical Geriatrics, 2025, 39(11): 1088-1092. |
| [9] | JIANG Peiming, XIAO Di, XIE Mengtong, ZHANG Yanchi, ZHANG Yupeng, YU Qiong. Application of artificial intelligence in sleep disorders of elderly [J]. Practical Geriatrics, 2025, 39(11): 1093-1097. |
| [10] | HU Xinyi, LI Dingkun, Aeryoubu, DUAN Jingyi, LIAO Xichu, GAO Haiying. Advances in multi-omics research on sleep disorders in elderly [J]. Practical Geriatrics, 2025, 39(10): 987-991. |
| [11] | XU Jie, WANG Yan, GU Xiaoping. Advances of polyphenols based on the microbial-gut-brain axis in neurodegenerative diseases [J]. Practical Geriatrics, 2025, 39(10): 1057-1061. |
| [12] | LI Maomao, MA Yanling, LI Jiehua. Effects of environmental exposure on sleep disorders [J]. Practical Geriatrics, 2025, 39(1): 17-21. |
| [13] | HUANG Mei, CHEN Hua-yu, JI Jing, ZHANG Li. Correlation of anxiety and depression with quality of life in elderly patients with Parkinson’s disease [J]. Practical Geriatrics, 2023, 37(1): 96-99. |
| [14] | ZHU Jun, ZHANG Li, XU Shu-lan, YAN Jun, ZHANG Juan, ZHU Yin, CHEN Shu. Study on sleep apnea hypopnea and cognitive injury in elderly patients with Parkinson’s disease [J]. Practical Geriatrics, 2022, 36(3): 240-243. |
| [15] | ZHOU En-zhu, XIA Li, LYU Yang, LIU Xin-tong. Study on the characteristics of sleep disorders in the elderly patients with dementia [J]. Practical Geriatrics, 2021, 35(6): 599-601. |
| Viewed | ||||||
|
Full text |
|
|||||
|
Abstract |
|
|||||
|