多酚基于微生物-肠-脑轴在神经退行性疾病中的研究进展

doi:10.3969/j.issn.1003-9198.2025.10.018

Abstract

Abstract: The aging population presents a growing challenge, while neurodegenerative diseases (NDs) still lack scientifically validated treatments. Recent studies have highlighted the gut microbiota’s role in neurological disorders, suggesting dietary modifications could optimize its composition to positively influence NDs. Evidence demonstrates that polyphenols’ anti-inflammatory and antioxidant properties may modulate central nervous system (CNS) activity through the microbiota-gut-brain axis, offering novel therapeutic approaches. This review reveals polyphenols’ protective mechanisms via this axis in NDs, identifying potential clinical strategies for managing these conditions.

Key words: polyphenols, microbiota, gut-brain axis, neurodegenerative diseases, antioxidants, anti-inflammatory effects

CLC Number:

R 741

XU Jie, WANG Yan, GU Xiaoping. Advances of polyphenols based on the microbial-gut-brain axis in neurodegenerative diseases[J]. Practical Geriatrics, 2025, 39(10): 1057-1061.

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Advances of polyphenols based on the microbial-gut-brain axis in neurodegenerative diseases

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