老年人睡眠障碍的多组学研究进展

doi:10.3969/j.issn.1003-9198.2025.10.004

Abstract

Abstract: With the advancement of social modernization and global population aging, sleep disorders among the elderly have become increasingly prominent. The elderly commonly experience difficulties in falling asleep, insufficient sleep duration, and frequent sleep interruptions. Poor sleep quality can lead to a range of health issues, including falls, fatigue, exhaustion, and subjective cognitive decline. Sleep disorders are complex polygenic conditions influenced by gene-environment interactions. By investigating the pathogenesis of various types of sleep disorders in the elderly population in China through multi-omics approaches (encompassing genomics, transcriptomics, proteomics, and metabolomics) as well as key molecular regulatory networks, novel regulatory targets for sleep disorders can be identified. These findings may provide both foundational and clinical scientific evidence to support the development of diagnosis and treatment strategies for sleep disorders in the elderly in China.

Key words: sleep disorders, multi-omics research, aged

CLC Number:

R 592

HU Xinyi, LI Dingkun, Aeryoubu, DUAN Jingyi, LIAO Xichu, GAO Haiying. Advances in multi-omics research on sleep disorders in elderly[J]. Practical Geriatrics, 2025, 39(10): 987-991.

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Advances in multi-omics research on sleep disorders in elderly

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