老年听力障碍的多组学研究进展

doi:10.3969/j.issn.1003-9198.2025.10.006

摘要/Abstract

摘要： 听力障碍是常见老年综合征之一,是第三大影响老年人生活质量的疾病,其发病机制复杂,是遗传、环境、代谢等多因素共同作用的结果。单一组学方法因其视角的局限性,难以系统地对这一疾病的复杂机制进行全面剖析。近年来,多组学技术的兴起,为全面揭示听力障碍发病机制提供了新的视野。本文综述了近年来基因组学、表观基因组学、转录组学、蛋白质组学、代谢组学及多组学联合在听力障碍领域中的最新研究进展。尽管多组学研究深化了对听力障碍机制的认识,但未来研究仍需深入机制探索及临床转化以推动听力障碍的精准防治。

关键词: 听力障碍, 老年综合征, 多组学, 研究进展

Abstract: Hearing impairment, one of the most prevalent age-related syndromes, ranks as the third leading health condition affecting quality of life in the eldery. Its complex pathogenesis results from the combined effects of genetic, environmental, and metabolic factors. While single-omics approaches are limitated in comprehensively analyzing this intricate mechanism, the recent emergence of multi-omics technologies has opened new avenues for revealing the pathogenic mechanisms of hearing disorders. This review synthesizes recent advancements in genomics, epigenomics, transcriptomics, proteomics, metabolomics, and multi-omics integration within the field of hearing impairment research. Although multi-omics studies have deepened our understanding of hearing disorder mechanisms, future research must focus on mechanistic exploration and clinical translation to advance precision prevention and treatment strategies.

Key words: hearing impairment, geriatric syndromes, multi-omics, research progress

中图分类号:

R 764.4

胡忠义, 杨旭玲. 老年听力障碍的多组学研究进展[J]. 实用老年医学, 2025, 39(10): 997-1002.

HU Zhongyi, YANG Xuling. Advances in multi-omics research on hearing impairment in elderly[J]. Practical Geriatrics, 2025, 39(10): 997-1002.

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