衰弱的多组学研究进展

doi:10.3969/j.issn.1003-9198.2025.10.003

摘要/Abstract

摘要： 衰弱是一种反映机体生理储备能力下降的老年综合征,严重影响老年人的生活质量。目前的研究表明,氧化应激和炎症等系统性过程均会加剧身体机能的衰退,但衰弱的具体发生机制尚未明确。采用精准的衰弱筛查技术以及明确衰弱的发病机制进而在衰弱的早期阶段进行识别和干预,是衰弱研究领域的重点和难点。基因组学、转录组学、蛋白质组学、代谢组学和微生物组学等多组学技术的快速发展让衰弱的研究进入了新的发展阶段。本文总结了衰弱研究中多组学方法的应用现状,强调了多组学技术在发现衰弱新型生物标志物和探索衰弱发病机制中的巨大潜力。

关键词: 衰弱, 多组学, 研究进展

Abstract: Frailty is a geriatric syndrome that reflects declining physiological reserve and strongly impairs quality of life of the elderly. Recently study implicated systemic processes such as oxidative stress and chronic inflammation in the acceleration of physical decline, yet the precise pathogenesis of frailty remains elusive. Accurate screening tools and a clear understanding of its molecular basis are therefore essential for early identification and intervention, which is the key challenges in frailty field. The rapid evolution of multi-omics technologies (including genomics, transcriptomics, proteomics, metabolomics, and microbiomics) has ushered frailty investigations into a new era. This paper reviews the current application of multi-omics approaches in frailty research, highlighting their immense potential for discovering novel biomarkers and exploring pathogenic mechanisms.

Key words: frailty, multi-omics, research advances

中图分类号:

R 592

张飞, 王子雯, 王津云, 吴迪珊, 王仲. 衰弱的多组学研究进展[J]. 实用老年医学, 2025, 39(10): 982-986.

ZHANG Fei, WANG Ziwen, WANG Jinyun, WU Dishan, WANG Zhong. Advances in multi-omics research on frailty[J]. Practical Geriatrics, 2025, 39(10): 982-986.

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