老年糖尿病病人认知衰弱的血液生物标志物研究进展

doi:10.3969/j.issn.1003-9198.2025.09.017

摘要/Abstract

摘要： 认知衰弱作为糖尿病的新型并发症,是指同时存在躯体衰弱和认知功能障碍,并排除AD及各种类型的痴呆,其对老年糖尿病病人的生存质量和预期寿命产生显著影响。与传统量表工具相比,血液生物标志物能够更早、更客观地识别出认知衰弱的高危人群。本文综述了近年来关于老年糖尿病病人认知衰弱的血液生物标志物研究进展,旨在为早期诊断、干预和治疗提供新的见解和策略。

关键词: 认知衰弱, 糖尿病, 生物标志物, 衰老

Abstract: Cognitive frailty, emerging as a novel complication of diabetes, is characterized by the coexistence of physical frailty and cognitive dysfunction, excluding Alzheimer’s disease and other dementias. It significantly affects the quality of life and life expectancy of elderly diabetic patients. Compared with traditional scale tools, blood biomarkers can identify high-risk groups of cognitive frailty earlier and more Objectively. This review summarizes recent advances in blood biomarkers of cognitive frailty in this population, aiming to provide new insights and strategies for early diagnosis, intervention, and treatment.

Key words: cognitive frailty, diabetes, biomarker, aging

中图分类号:

R 587.1

闫璐, 段宇. 老年糖尿病病人认知衰弱的血液生物标志物研究进展[J]. 实用老年医学, 2025, 39(9): 942-946.

YAN Lu, DUAN Yu. Research advances in blood-based biomarkers of cognitive frailty in elderly patients with diabetes mellitus[J]. Practical Geriatrics, 2025, 39(9): 942-946.

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