老年人睡眠障碍的多组学研究进展

doi:10.3969/j.issn.1003-9198.2025.10.004

摘要/Abstract

摘要： 随着社会现代化和全球老龄化进展,老年人睡眠障碍问题日益突出,老年人容易入睡困难、睡眠时间不足、睡眠中断。低质量的睡眠会导致一系列健康问题,如跌倒、疲劳、乏力、主观认知功能下降等。睡眠障碍是受基因与环境交互作用影响的多基因遗传病,本文从基因、转录、蛋白、代谢多组学检测及关键分子调控网角度,分析我国老年人不同类型睡眠障碍的发病机制,提出睡眠障碍调控新靶点,为老年人睡眠障碍的诊疗方案提供基础和临床科学证据。

关键词: 睡眠障碍, 多组学研究, 老年人

Abstract: With the advancement of social modernization and global population aging, sleep disorders among the elderly have become increasingly prominent. The elderly commonly experience difficulties in falling asleep, insufficient sleep duration, and frequent sleep interruptions. Poor sleep quality can lead to a range of health issues, including falls, fatigue, exhaustion, and subjective cognitive decline. Sleep disorders are complex polygenic conditions influenced by gene-environment interactions. By investigating the pathogenesis of various types of sleep disorders in the elderly population in China through multi-omics approaches (encompassing genomics, transcriptomics, proteomics, and metabolomics) as well as key molecular regulatory networks, novel regulatory targets for sleep disorders can be identified. These findings may provide both foundational and clinical scientific evidence to support the development of diagnosis and treatment strategies for sleep disorders in the elderly in China.

Key words: sleep disorders, multi-omics research, aged

中图分类号:

R 592

胡心一, 李丁坤, 阿尔有布, 段景宜, 廖锡楚, 高海英. 老年人睡眠障碍的多组学研究进展[J]. 实用老年医学, 2025, 39(10): 987-991.

HU Xinyi, LI Dingkun, Aeryoubu, DUAN Jingyi, LIAO Xichu, GAO Haiying. Advances in multi-omics research on sleep disorders in elderly[J]. Practical Geriatrics, 2025, 39(10): 987-991.

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