听力障碍与阿尔茨海默病相关性的Meta分析

doi:10.3969/j.issn.1003-9198.2023.09.013

摘要/Abstract

摘要： 目的系统评价听力障碍与AD的相关性。方法检索PubMed、Web of Science、EmBase、Cochrane Library、中国知网(CNKI)、万方数据库、维普网(VIP)和中国生物医学文献服务系统(SinoMed)中听力障碍与AD相关的研究,检索时间为建库至2022-03-28。采用Review Manager 5.4软件进行Meta分析,计算最终纳入研究的合并RR和95%CI,并进行敏感性分析和漏斗图偏倚检验。结果最终纳入6篇英文文献,Meta分析结果显示,听力障碍病人AD发生风险合并RR值为3.00(95%CI:1.58～5.70),差异有统计学意义(P＝0.0008)。结论听力障碍与AD之间存在相关性,听力障碍病人AD的发生风险显著高于听力正常者。对于出现听力障碍的人群,应及早采取措施进行干预,减缓其认知功能的下降。

关键词: 听力障碍, 阿尔茨海默病, Meta分析

Abstract: Objective To evaluate the association between hearing impairment and Alzheimer's disease. Methods The studies on the correlation between hearing impairment and Alzheimer's disease in PubMed, Web of Science, EmBase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Database, VIP and SinoMed were retrievaled by computer, and the retrieval time was from database establishment to March 28th, 2022. Review Manager 5.4 software was used for Meta-analysis. The combined risk ratio (RR) and 95% confidence interval (CI) of the included literatures were calculated,and sensitivity analysis and funnel plot bias test were carried out. Results Finally, six English literatures were enrolled. The results of Meta-analysis showed that the combined RR value of Alzheimer's disease in the patients with hearing impairment was 3.00 (95% CI: 1.58-5.70,P=0.0008). Conclusions There is a correlation between hearing impairment and Alzheimer's disease. The risk of Alzheimer's disease in the patients with hearing impairment is significantly increased.For the people presenting with hearing impairment, early intervention measures should be taken to slow down the cognitive decline.

Key words: hearing impairment, Alzheimer's disease, Meta-analysis

中图分类号:

R 749.16

王敏, 郭文军, 汤忠泉, 赵晓敏, 欧婷, 李云涛. 听力障碍与阿尔茨海默病相关性的Meta分析[J]. 实用老年医学, 2023, 37(9): 915-919.

WANG Min, GUO Wen-jun, TANG Zhong-quan, ZHAO Xiao-min, OU Ting, LI Yun-tao. Association between hearing impairment and Alzheimer's disease: a Meta-analysis[J]. Practical Geriatrics, 2023, 37(9): 915-919.

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