胶质淋巴系统在阿尔茨海默病中的作用

doi:10.3969/j.issn.1003-9198.2024.08.004

摘要/Abstract

摘要： 胶质淋巴系统是中枢神经系统中进行脑脊液-脑组织液交换的主要结构。星形胶质细胞上的水通道蛋白4(aquaporin 4,AQP4)是胶质淋巴系统的必需结构,AQP4在星形胶质细胞的终足极化分布,与血管周围空间紧密接触,从而促进脑脊液流入脑实质,可以清除包括β-淀粉样蛋白(amyloid β-protein, Aβ)、神经纤维缠结蛋白在内的多种代谢产物。在AD中,Aβ沉积、神经纤维缠结蛋白作为主要病理改变,它们的产生可以被认为是和清除不平衡的结果,因此,增加其在中枢神经系统中的清除率可作为改善AD认知障碍的一种新思路。通过对有关胶质淋巴系统在AD中的作用研究,可以为AD等神经退行性疾病的发病机制和诊疗策略带来新的认识。

关键词: 阿尔茨海默病, 胶质淋巴系统, 水通道蛋白4, β-淀粉样蛋白

中图分类号:

R749.16

刘乐乐, 解瑞川, 支楠, 高丽. 胶质淋巴系统在阿尔茨海默病中的作用[J]. 实用老年医学, 2024, 38(8): 770-774.

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