主观认知下降转归为阿尔茨海默病的研究现状

doi:10.3969/j.issn.1003-9198.2024.04.020

摘要/Abstract

摘要： AD是一种常见的老年人慢性神经退行性疾病,目前尚无特效疗法能阻止或逆转其病情进展。主观认知下降(subjective cognitive decline,SCD)近年来被认为是AD的临床前期症状。本文简要综述了SCD人群的不同转归结局,并从神经心理评估、人口学、影像学和生物标记物等方面归纳总结了SCD转归为AD的高风险因素,期望临床工作者关注SCD人群,早期识别风险因素,以延缓病情的发生发展。

关键词: 主观认知下降, 轻度认知功能障碍, 阿尔茨海默病, 痴呆, 预后

中图分类号:

R 749.1

王慧娟, 李霞. 主观认知下降转归为阿尔茨海默病的研究现状[J]. 实用老年医学, 2024, 38(4): 414-417.

参考文献

[1] GARRE-OLMO J. Epidemiology of Alzheimer's disease and other dementias[J]. Rev Neurol, 2018, 66(11): 377-386.
[2] JIA J, WEI C, CHEN S, et al. The cost of Alzheimer's disease in China and re-estimation of costs worldwide[J]. Alzheimers Dement, 2018,14(4): 483-491.
[3] JACK C R, KNOPMAN D S, JAGUST W J, et al. Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers[J]. Lancet Neurol, 2013, 12(2): 207-216.
[4] RABIN L A, SMART C M, AMARIGLIO R E. Subjective cognitive decline in preclinical Alzheimer's disease[J]. Annu Rev Clin Psychol, 2017, 13: 369-396.
[5] BUCKLEY R F, MARUFF P, AMES D, et al. Subjective memory decline predicts greater rates of clinical progression in preclinical Alzheimer's disease[J]. Alzheimers Dement, 2016, 12(7): 796-804.
[6] DONOVAN N J, AMARIGLIO R E, ZOLLER A S, et al. Subjective cognitive concerns and neuropsychiatric predictors of progression to the early clinical stages of Alzheimer disease[J]. Am J Geriatr Psychiatry, 2014, 22(12): 1642-1651.
[7] REISBERG B, SHULMAN M B, TOROSSIAN C, et al. Outcome over seven years of healthy adults with and without subjective cognitive impairment[J]. Alzheimers Dement, 2010, 6(1): 11-24.
[8] ABNER E L, KRYSCIO R J, CABAN-HOLT A M, et al. Baseline subjective memory complaints associate with increased risk of incident dementia: the PREADVISE trial[J]. J Prev Alzheimers Dis, 2015, 2(1): 11-16.
[9] MITCHELL A J, BEAUMONT H, FERGUSON D, et al. Risk of dementia and mild cognitive impairment in older people with subjective memory complaints: meta-analysis[J]. Acta Psychiatr Scand, 2014, 130(6): 439-451.
[10] JIA F, LI Y, LI M, et al. Subjective cognitive decline, cognitive reserve indicators, and the incidence of dementia[J]. J Am Med Dir Assoc, 2021, 22(7): 1449-1455.
[11] MAZZEO S, PADIGLIOI S, BAGNOLI S, et al. Assessing the effectiveness of subjective cognitive decline plus criteria in predicting the progression to Alzheimer's disease: an 11-year follow-up study[J]. Eur J Neurol, 2020, 27(5): 894-899.
[12] ST JOH P, MONTGOMERY P. Are cognitively intact seniors with subjective memory loss more likely to develop dementia? [J]. Int J Geriatr Psychiatry, 2002, 17: 814-820.
[13] YUE L, HU D, ZHANG H, et al. Prediction of 7-year's conversion from subjective cognitive decline to mild cognitive impairment[J]. Hum Brain Mapp, 2021, 42(1): 192-203.
[14] XU W, TAN L, WANG H F, et al. Education and risk of dementia: dose-response Meta-analysis of prospective cohort studies[J]. Mol Neurobiol, 2016, 53(5): 3113-3123.
[15] LIVINGSTON G, HUNTLEY J, SOMMERLAD A, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission[J]. Lancet, 2020, 396(10248): 413-446.
[16] DESAI R, WHITFIELD T, SAID G, et al. Affective symptoms and risk of progression to mild cognitive impairment or dementia in subjective cognitive decline: a systematic review and meta-analysis[J]. Ageing Res Rev, 2021, 71: 101419.
[17] MARCHANT N L, HOWARD R J. Cognitive debt and Alzheimer's disease[J]. J Alzheimers Dis, 2015, 44(3): 755-770.
[18] MARCHANT N L, LOVLAND L R, JONES R, et al. Repetitive negative thinking is associated with amyloid, tau, and cognitive decline[J]. Alzheimers Dement, 2020, 16(7): 1054-1064.
[19] ZHU D, MONTAGNE A, ZHAO Z. Alzheimer's pathogenic mechanisms and underlying sex difference[J]. Cell Mol Life Sci, 2021, 78(11): 4907-4920.
[20] BESSI V, MAZZEO S, PADIGLIONI S, et al. From subjective cognitive decline to Alzheimer's disease: the predictive role of neuropsychological assessment, personality traits, and cognitive reserve. a 7-year follow-up study[J]. J Alzheimers Dis, 2018, 63: 1523-1535.
[21] MAZZEO S, PADIGLIONI S, BAGNOLI S, et al. The dual role of cognitive reserve in subjective cognitive decline and mild cognitive impairment: a 7-year follow-up study[J]. J Neurol, 2019, 266(2): 487-497.
[22] GONNEAUD J, BEDETTI C, PICHET BINETTE A, et al. Association of education with Aβ burden in preclinical familial and sporadic Alzheimer disease[J]. Neurology, 2020, 95(11): 1554-1564.
[23] HU X, TEUNISSEN C E, SPOTTKE A, et al. Smaller medial temporal lobe volumes in individuals with subjective cognitive decline and biomarker evidence of Alzheimer's disease-data from three memory clinic studies[J]. Alzheimers Dement, 2019, 15(2): 185-193.
[24] PITTI H, DIAZ-GALVAN P, BARROSO J, et al. Cerebrovascular damage in subjective cognitive decline: a systematic review and meta-analysis[J]. Ageing Res Rev, 2022, 82: 101757-101757.
[25] SLOT R E R, SIKKES S A M, BERKHOF J, et al. Subjective cognitive decline and rates of incident Alzheimer's disease and non-Alzheimer's disease dementia[J]. Alzheimers Dement, 2019, 15(3): 465-476.
[26] HAROLD D, ABRAHAM R, HOLLINGWORTH P, et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease[J]. Nat Genet, 2009, 41(10): 1088-1093.
[27] ALI J I, SMART C M, GAWRYLUK J R. Subjective cognitive decline and APOE ε4: a systematic review[J]. J Alzheimers Dis, 2018, 65(1): 303-320.
[28] VAN HARTEN A C, SMIT L L, TEUNISSEN C E, et al. Preclinical AD predicts decline in memory and executive functions in subjective complaints[J]. Neurology, 2013, 81: 1409-1416.
[29] VOGEL J W, VARGA DOLEZALOVA M, LA JOIE R, et al. Subjective cognitive decline and β-amyloid burden predict cognitive change in healthy elderly[J]. Neurology, 2017, 89(19): 2002-2009.
[30] DUBOIS B, EPELBAUM S, NYASSE F, et al. Cognitive and neuroimaging features and brain beta-amyloidosis in individuals at risk of Alzheimer's disease (INSIGHT-preAD): A longitudinal observational study[J]. Lancet Neurol, 2018, 17(4), 335-346.