益生菌治疗对肌少症合并认知障碍的作用及机制

doi:10.3969/j.issn.1003-9198.2026.01.017

Abstract

Abstract: Sarcopenia and cognitive impairment are highly prevalent degenerative diseases in the elderly population, which severely affect patients’ quality of life and prognosis. However, current clinical intervention strategies for this comorbidity remain relatively limited. This article summarizes previous studies on the effects of probiotics on sarcopenia and cognitive impairment, and explores the feasibility of probiotic supplementation in achieving synergistic intervention for sarcopenia with cognitive impairment. The mechanism involves reshaping the structure of gut microbiota, thereby regulating the profile of gut microbiota metabolites, modulating the levels of key cellular signaling pathways and inflammatory cytokines, thus offering novel insights and strategic directions for the clinical diagnosis and management of these patients.

Key words: probiotics, gut microbiota, sarcopenia, cognitive impairment

CLC Number:

HE Haihua, LIU Gaoshuang, OUYANG Xiaojun. Effects and mechanisms of probiotics on sarcopenia complicated with cognitive impairment[J]. Practical Geriatrics, 2026, 40(1): 83-88.

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Effects and mechanisms of probiotics on sarcopenia complicated with cognitive impairment

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