阿尔茨海默病性别差异机制研究进展

doi:10.3969/j.issn.1003-9198.2025.04.020

Abstract

Abstract: Alzheimer’s disease (AD) is a neurodegenerative disorder that exhibits gender differences in epidemiology, clinical symptoms, neuroimaging and biomarkers. The underlying mechanisms contributing to these differences remain unclear. Current research suggests that sex chromosomes, sex hormones, apolipoprotein E, inflammatory and immune factors, and vascular disease-related factors may be involved in the gender-specific mechanisms of AD susceptibility. However, more research evidence is needed to support these findings and to identify new intervention targets, thereby promoting precision diagnosis and treatment for AD.

Key words: Alzheimer’s disease, gender differences, sex chromosomes, sex hormones, apolipoprotein E, immune inflammation, vascular disease

CLC Number:

R 749.16

LIN Xiaoqi, ZHAO Xinjing, WU Yashuang, ZHAO Wei, CHEN Chen, GAO Tianyu, ZHOU Guoyu. Advances of the mechanisms of gender differences in Alzheimer’s disease[J]. Practical Geriatrics, 2025, 39(4): 420-425.

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Advances of the mechanisms of gender differences in Alzheimer’s disease

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