Abstract: Objective To explore the influencing factors of deep medullary vein(DMV) visual score and the correlation between total burden of cerebral small vessel disease(CSVD) and DMV visual score. Methods A total of 180 CSVD patients admitted to Tangshan Workers' Hospital were enrolled in this study. The correlation between DMV visual score and the total burden of CSVD was analyzed by Spearman correlation analysis. Multivariate ordinal Logistic regression analysis was performed to analyze the relevant factors of DMV visual score. Results DMV visual score was positively correlated with the total burden of CSVD(r=0.760, P<0.001). Multivariate ordinal Logistic regression analysis showed that age(OR=1.280, 95%CI: 1.208-1.355, P<0.001), lacune of presumed vascular origin(LPVO)(OR=4.679, 95% CI: 2.234-9.800, P<0.001), cerebral microbleed(CMB)(OR=3.605, 95%CI: 1.855-7.003, P<0.001), perivascular space(PVS)(OR=2.588, 95%CI: 1.179-5.682, P=0.018), and white matter hyperintensity(WMH)(OR=7.440, 95%CI: 3.279-16.880, P<0.001) were the independent influencing factors of DMV visual scores. Conclusions There is a strong correlation between DMV visual score and the total burden of CSVD, and the worse the visibility of DMV is, the more severe the overall brain damage of CSVD is. Age, LPVO, CMB, PVS, and WMH show significant influence on DMV visual score.

Key words: deep medullary vein visual score, total burden of cerebrovascular disease, influencing factor