Abstract: Frailty is a geriatric syndrome that reflects declining physiological reserve and strongly impairs quality of life of the elderly. Recently study implicated systemic processes such as oxidative stress and chronic inflammation in the acceleration of physical decline, yet the precise pathogenesis of frailty remains elusive. Accurate screening tools and a clear understanding of its molecular basis are therefore essential for early identification and intervention, which is the key challenges in frailty field. The rapid evolution of multi-omics technologies (including genomics, transcriptomics, proteomics, metabolomics, and microbiomics) has ushered frailty investigations into a new era. This paper reviews the current application of multi-omics approaches in frailty research, highlighting their immense potential for discovering novel biomarkers and exploring pathogenic mechanisms.

Key words: frailty, multi-omics, research advances