老年抑郁症的多组学研究进展

doi:10.3969/j.issn.1003-9198.2025.10.002

Abstract

Abstract: Late-life depression (LLD), characterized by complex pathogenesis and heterogeneous clinical manifestations, has become a significant public health challenge in aging societies. This review systematicly synthesizes the latest advancements in genomic, epigenomic, transcriptomic, proteomic, metabolomic, and multi-omics integrated studies on LLD, provides novel biomarkers and therapeutic strategies for early diagnosis, prognosis assessment, and personalized treatment. Future research should focus on achieving breakthroughs in large-scale cross-ethnic validation, biomarkers translation, and age-related interventions.

Key words: aged, depression, multi-omics research

CLC Number:

R 749.4

ZHANG Kongyan. Advances in multi-omics research on depression in the elderly[J]. Practical Geriatrics, 2025, 39(10): 976-981.

References

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Advances in multi-omics research on depression in the elderly

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