血清sirtuin1、sirtuin6联合预测老年冠心病病人合并衰弱的效能

doi:10.3969/j.issn.1003-9198.2025.08.013

Abstract

Abstract: Objective To explore the efficacy of serum silent information regulator protein (sirtuin)1 combined with sirtuin6 in predicting frailty in the elderly patients with coronary heart disease (CHD). Methods A total of 235 elderly CHD patients admitted to Guangyuan First People’s Hospital from May 2022 to July 2024 were enrolled. All patients were divided into the frailty group (81 cases) and the non-frailty group (154 cases). The general clinical data were collected and the serum levels of sirtuin1 and sirtuin6 were measured by enzyme-linked immunosorbent assay. The influencing factors of frailty in the elderly CHD patients were analyzed by univariate analysis and multivariate unconditional logistic regression. The predictive value of serum sirtuin1 and sirtuin6 for frailty were analyzed by receiver operating characteristic(ROC) curve. Results Among the 235 elderly CHD patients, the incidence rate of frailty was 34.47% (81/235). Age, New York Heart Association (NYHA) cardiac function classification, malnutrition, history of falls within the past year, the levels of albumin and hemoglobin showed statistically significant differences between the two groups (all P<0.05). Compared to the non-frailty group, the serum sirtuin1 and sirtuin6 levels were lower in the frailty group (P<0.05). Multivariate logistic regression analysis showed that age, NYHA functional class Ⅲ, malnutrition, decreased levels of sirtuin1 and sirtuin6 were independent risk factors for frailty in the elderly CHD patients (P<0.05). The area under ROC curve (AUC) of sirtuin1 combined with sirtuin6 in predicting frailty was 0.890, which was significantly higher than that of sirtuin1 (0.811) and sirtuin6 (0.800) alone (all P<0.05). Conclusions Decreased serum sirtuin1 and sirtuin6 levels are risk factors for frailty in elderly patients with CHD, and the combination of serum sirtuin1 and sirtuin6 has high predictive efficiency.

Key words: aged, coronary heart disease, frailty, silent information regulator protein 1, silent information regulator protein 6

CLC Number:

R541.4
R592

HAN Dan, LIU Pan, WANG Xiaoying, ZHAO Yuanyuan, DU Changhong. Efficacy of serum sirtuin1 combined with sirtuin6 in predicting frailty in elderly patients with coronary heart disease[J]. Practical Geriatrics, 2025, 39(8): 818-821.

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Efficacy of serum sirtuin1 combined with sirtuin6 in predicting frailty in elderly patients with coronary heart disease

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