益生菌治疗对肌少症合并认知障碍的作用及机制

doi:10.3969/j.issn.1003-9198.2026.01.017

摘要/Abstract

摘要： 肌少症与认知障碍作为老年人群中高发的退行性疾病,严重影响病人的生活质量与预后,但目前针对该合并症的临床干预手段仍较为有限。本文总结了既往益生菌对肌少症合并认知障碍影响的研究,探讨益生菌治疗通过重塑肠道菌群结构,进而调控肠道菌群代谢产物谱,调节关键细胞信号通路及炎性细胞因子水平,最终实现对肌少症合并认知障碍协同干预的可行性,期望为该人群的临床治疗与健康管理提供新的思路与研究方向。

关键词: 益生菌, 肠道菌群, 肌少症, 认知障碍

Abstract: Sarcopenia and cognitive impairment are highly prevalent degenerative diseases in the elderly population, which severely affect patients’ quality of life and prognosis. However, current clinical intervention strategies for this comorbidity remain relatively limited. This article summarizes previous studies on the effects of probiotics on sarcopenia and cognitive impairment, and explores the feasibility of probiotic supplementation in achieving synergistic intervention for sarcopenia with cognitive impairment. The mechanism involves reshaping the structure of gut microbiota, thereby regulating the profile of gut microbiota metabolites, modulating the levels of key cellular signaling pathways and inflammatory cytokines, thus offering novel insights and strategic directions for the clinical diagnosis and management of these patients.

Key words: probiotics, gut microbiota, sarcopenia, cognitive impairment

中图分类号:

何海华, 刘高双, 欧阳晓俊. 益生菌治疗对肌少症合并认知障碍的作用及机制[J]. 实用老年医学, 2026, 40(1): 83-88.

HE Haihua, LIU Gaoshuang, OUYANG Xiaojun. Effects and mechanisms of probiotics on sarcopenia complicated with cognitive impairment[J]. Practical Geriatrics, 2026, 40(1): 83-88.

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