实用老年医学

实用老年医学 ›› 2024, Vol. 38 ›› Issue (5): 495-437.doi: 10.3969/j.issn.1003-9198.2024.05.015

• 临床研究 • 上一篇    下一篇

糖代谢异常对血清激活素A水平的影响

刘童君, 赵雅洁, 胡洁玲, 胡洋, 梁伟   

  1. 200025 上海市,上海交通大学医学院附属瑞金医院老年科(刘童君,赵雅洁,胡洁玲,梁伟);
    266034 山东省青岛市,山东大学齐鲁医院(青岛)放射科(胡洋)
  • 收稿日期:2023-06-21 出版日期:2024-05-20 发布日期:2024-05-23
  • 通讯作者: 梁伟,Email: lw10920@rjh.com.cn
  • 基金资助:
    上海市卫生健康委员会卫生行业临床研究专项项目(202140052)

Effect of glucose metabolic disorders on serum levels of activin-A

LIU Tongjun, ZHAO Yajie, HU Jieling, HU Yang, LIANG Wei   

  1. Department of Geriatrics, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China (LIU Tongjun, ZHAO Yajie, HU Jieling, LIANG Wei);
    Department of Radiology, Qilu Hospital (Qingdao), Shandong University, Qingdao 266034, China (HU Yang）
  • Received:2023-06-21 Online:2024-05-20 Published:2024-05-23
  • Contact: LIANG Wei, Email: lw10920@rjh.com.cn

PDF (PC)

460

摘要： 目的 探讨老年人群血清激活素A(ACT-A)的表达情况及其在不同血糖状态病人中的影响因素。 方法 纳入2022年7月至2023年2月期间瑞金医院特需病房体检人群293例,检测其血清ACT-A水平,分析不同临床特征病人ACT-A的表达差异及不同血糖状态病人中ACT-A的影响因素。 结果 ACT-A水平随着年龄的增长和糖尿病病情进展均升高(P<0.01)。HbA1c≥7%、合并有中度肾功能不全、高血压病史、脉压>55 mmHg及脉压指数>0.45的老年糖尿病病人ACT-A水平更高。糖尿病人群中,Pearson相关分析及线性回归均证实ACT-A水平与年龄、HbA1c及胰岛素抵抗指数(HOMA-IR)呈正相关(P均<0.05),与空腹胰岛素水平呈负相关(P<0.05)。 结论 衰老个体体内ACT-A水平增加,且与年龄呈正相关;ACT-A水平在糖尿病前期即可升高,在糖尿病阶段进一步升高;年龄、HbA1c、空腹胰岛素及HOMA-IR与糖尿病病人ACT-A水平独立相关。

关键词: 激活素A, 衰老, 糖尿病, 糖尿病前期

Abstract: Objective To explore the expression of serum ACT-A in the elderly with different glucose staus. Methods A total of 293 stable patients who underwent physical examination in the VIP department of Ruijin Hospital from July 2022 to February 2023 were enrolled. The serum ACT-A level was detected, and the expression differences of ACT-A in the patients with different clinical characteristics and the influencing factors in the patients with different glucose status were analyzed. Results The level of ACT-A increased with age and the progression of diabetes (P<0.01). The level of ACT-A was higher in elderly diabetic patients with HbA1c≥7%, renal insufficiency, hypertension history, pulse pressure>55 mmHg and pulse pressure index>0.45. In diabetes population, Pearson correlation analysis and linear regression confirmed that the level of ACT-A was positively correlated with age, HbA1c, and HOMA-IR(B=20.996, 33.391, 57.482, P<0.05), and negatively correlated with the level of fasting insulin(B=-17.794, P<0.05). Conclusions The level of ACT-A is positively correlated with age. The level of ACT-A can be increased in the patients with prediabetes, and further increased in the patients with diabetes. Age, HbA1c, HOMA-IR and fasting insulin are independently associated with ACT-A level in diabetic patients.

Key words: activin-A, aged, diabetes mellitus, prediabetes

中图分类号: