衰老积累的表观遗传学改变与肿瘤的发生发展

doi:10.3969/j.issn.1003-9198.2024.09.021

摘要/Abstract

摘要： 衰老是所有生物共有的复杂的多因素生物学过程,它表现为正常生理功能随时间的变化而逐渐下降。机体衰老过程中会发生DNA甲基化整体水平的降低,组蛋白甲基化及乙酰化的异常修饰,染色质重塑导致的DNA损伤和非编码RNA的异常表达等表观遗传学改变。随着表观遗传学改变的积累,基因表达或染色体稳定性发生可遗传的变化,从而诱导肿瘤相关基因的活化或抑制,驱动肿瘤的发生发展。本文综述了衰老导致的表观遗传学改变以及从表观遗传学角度阐述衰老与肿瘤之间的因果关系,为基于表观遗传学治疗肿瘤提供新的途径。

关键词: 衰老, 表观遗传, 肿瘤, DNA甲基化, 组蛋白, 染色质重塑, 非编码RNA

中图分类号:

R339.38
Q34

孙泽东, 任斌辉. 衰老积累的表观遗传学改变与肿瘤的发生发展[J]. 实用老年医学, 2024, 38(9): 953-957.

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