钙卫蛋白S100A8/S100A9在阿尔茨海默病中的研究进展

doi:10.3969/j.issn.1003-9198.2025.02.020

摘要/Abstract

摘要： AD是一种以进行性记忆丧失为特征的疾病。基于微生物-肠-脑轴这一新兴学说,我们认为肠道菌群变化可以激活肠道炎症反应。钙卫蛋白作为肠道炎症标志物,是AD脑肠轴学说中的关键物质,其亚基S100A8、S100A9也分别与AD中的β-淀粉样蛋白(Aβ)学说、神经炎症学说密切相关。本文归纳了S100A8/S100A9蛋白的主要功能及其在AD发病中的相关机制、危险因素、预防和治疗方面的新进展,以期为AD的治疗提供新的研究方向。

关键词: 阿尔茨海默病, 钙卫蛋白, S100A9, S100A8

Abstract: Alzheimer's disease(AD) is characterized by progressive memory loss. Based on the emerging theory of microbe-gut-brain axis, the changes in intestinal flora might activate the intestinal inflammation. Calprotectin, as a marker of intestinal inflammation, is a key substance in the brain-gut axis of AD. Its subunits S100A8 and S100A9 are also closely related to the Aβ theory and neuroinflammation theory in AD, respectively. Therefore, this article reviews the main functions of S100A8/S100A9 protein and its new research progress in AD-related pathogenesis, risk factors, prevention and treatment, in order to provide new research directions for the treatment of AD.

Key words: Alzheimer's disease, calprotectin, S100A9, S100A8

中图分类号:

R 749.16

吴金丽, 杨晓娟. 钙卫蛋白S100A8/S100A9在阿尔茨海默病中的研究进展[J]. 实用老年医学, 2025, 39(2): 197-201.

WU Jinli, YANG Xiaojuan. Research progress of calprotectin S100A8/S100A9 in Alzheimer's disease[J]. Practical Geriatrics, 2025, 39(2): 197-201.

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