阿卡波糖通过模拟热量限制延缓衰老:降糖之外的惊喜

doi:10.3969/j.issn.1003-9198.2024.02.020

摘要/Abstract

摘要： 热量限制(CR)在延缓衰老、防治2型糖尿病、肥胖等代谢性疾病中的意义和优势不言而喻,然而,长期实施CR依然面临很大挑战。热量限制模拟剂(CRMs)旨在不限制饮食的基础上模拟CR的效果,通过调节能量代谢、激活自噬、调控长寿基因表达等途径达到抗衰老的作用。阿卡波糖作为一种广泛使用的降糖药物,在临床和基础研究中被初步证实可以延长寿命、延缓肿瘤生长、减少衰老相关疾病的发生,故有望成为CRMs候选药物之一。本文主要从CR模拟角度探讨阿卡波糖延缓衰老的可能机制,为其助力人类健康提供初步理论依据。

关键词: 阿卡波糖, 热量限制模拟, 衰老, 寿命

中图分类号:

R 977.15

刘元君, 吴怡, 金丽娟. 阿卡波糖通过模拟热量限制延缓衰老:降糖之外的惊喜[J]. 实用老年医学, 2024, 38(2): 189-192.

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