肠道菌群代谢产物调控骨骼肌稳态的分子机制及其在衰弱中的意义

doi:10.3969/j.issn.1003-9198.2026.02.016

Abstract

Abstract: Frailty is a syndrome associated with aging, characterized by a decline in physiological reserve and reduced resilience to stress. Sarcopenia, a closely related degenerative condition, is characterized by age-related reductions in skeletal muscle mass and function, which severely affects the quality of life and independence of older adults. Based on the complex regulatory interactions of the gut-muscle axis, this review summarizes how gut microbiota-derived metabolites such as short-chain fatty acids, amino acid derivatives, and secondary bile acids affect skeletal muscle homeostasis by regulating inflammation/immune responses, energy metabolism, endocrine signaling, and insulin sensitivity. The aim is to elucidate the pathophysiological processes of sarcopenia and provide a theoretical basis for developing novel intervention strategies.

Key words: gut microbiota, metabolite, skeletal muscle, frailty, sarcopenia, mechanism

CLC Number:

R 685
R 592

SHI Haiyan, MA Yan, GUO Ruifang. Molecular mechanisms of gut microbiota-derived metabolites in regulating skeletal muscle homeostasis and their significance for frailty[J]. Practical Geriatrics, 2026, 40(2): 185-190.

References

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Molecular mechanisms of gut microbiota-derived metabolites in regulating skeletal muscle homeostasis and their significance for frailty

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