Practical Geriatrics ›› 2025, Vol. 39 ›› Issue (9): 942-946.doi: 10.3969/j.issn.1003-9198.2025.09.017

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Research advances in blood-based biomarkers of cognitive frailty in elderly patients with diabetes mellitus

YAN Lu, DUAN Yu   

  1. Division of Geriatric Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
  • Received:2025-03-13 Online:2025-09-20 Published:2025-09-19
  • Contact: DUAN Yu, Email: duanyu@jsph.org.cn

Abstract: Cognitive frailty, emerging as a novel complication of diabetes, is characterized by the coexistence of physical frailty and cognitive dysfunction, excluding Alzheimer’s disease and other dementias. It significantly affects the quality of life and life expectancy of elderly diabetic patients. Compared with traditional scale tools, blood biomarkers can identify high-risk groups of cognitive frailty earlier and more Objectively. This review summarizes recent advances in blood biomarkers of cognitive frailty in this population, aiming to provide new insights and strategies for early diagnosis, intervention, and treatment.

Key words: cognitive frailty, diabetes, biomarker, aging

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