Practical Geriatrics ›› 2025, Vol. 39 ›› Issue (9): 937-941.doi: 10.3969/j.issn.1003-9198.2025.09.016

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Research progress on the correlation between Alzheimer’s disease and osteoporosis

WANG Miaohui, FAN Xuhang, CHEN Siyao, YANG Xiaojuan   

  1. The First Clinical Medical College of Shanxi Medical University, Taiyuan 030000, China(WANG Miaohui, FAN Xuhang, CHEN Siyao); Department of Geriatrics, the First Hospital of Shanxi Medical University, Taiyuan 030000, China(YANG Xiaojuan)
  • Received:2024-12-17 Online:2025-09-20 Published:2025-09-19
  • Contact: YANG Xiaojuan, Email: yangxiaojuan@sxmu.edu.cn

Abstract: With the acceleration of the global aging, the incidences of Alzheimer’s disease (AD) and osteoporosis (OP) are increasing year by year, and they both seriously affect the quality of life and healthspan of the elderly. In recent years, more and more studies have focused on the correlation between AD and OP, exploring their common risks, including inflammatory responses, vitamin D deficiency, hormonal imbalances, and genetic factors. Epidemiological studies have shown that the two diseases often occur concomitantly and affect each other. This review summarizes the research progress on their common physiological and pathological aspects, epidemiology, and the mechanisms of mutual influence. A deep understanding of the association between AD and OP is expected to provide new ideas and strategies for early diagnosis, prevention, and comprehensive treatment, ultimately improving the prognosis of patients and reducing the burden on families and society.

Key words: Alzheimer’s disease, osteoporosis, epidemiology, correlation mechanism

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