蛋白质酶促糖基化修饰在阿尔茨海默病中的研究进展

doi:10.3969/j.issn.1003-9198.2025.06.020

Abstract

Abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by a decline in cognitive function and self-care ability, often accompanied by mental and behavioral abnormalities. The incidence of AD increases with age. Enzymatic protein glycosylation, a critical post-translational modification, plays a significant role in the development of AD, and N-linked glycosylation and O-linked glycosylation are closely associated with the development of AD. This review provides insights into the underlying pathogenesis, as well as to explore potential early diagnostic approaches and novel therapeutic strategies.

Key words: enzymatic protein glycosylation, post-translational modifications, Alzheimer’s disease

CLC Number:

R749.13

GU Xingyue, GAO Wei, LU Xiang. Advances in the study of enzymatic protein glycosylation in Alzheimer’s disease[J]. Practical Geriatrics, 2025, 39(6): 631-635.

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Advances in the study of enzymatic protein glycosylation in Alzheimer’s disease

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