Abstract: Objective To investigate the prevalence of chronic kidney disease (CKD) and its influencing factors among community-based elderly individuals undergoing health examinations in Nanjing. Methods A cross-sectional study was conducted among adults aged 65 years and older who were enrolled in the National Essential Public Health Service project in Nanjing in 2022. A total of 6000 participants were randomly selected using proportional sampling for analysis. CKD was defined as an estimated glomerular filtration rate (eGFR)<60 mL/(min·1.73 m²) calculated using the CKD-EPI equation. T-tests and chi-square tests were used to compare differences in the clinical data between the CKD group and the non-CKD group. Univariate and multivariate logistic regression models were employed to analyze the risk factors of CKD. Results The overall prevalence of CKD among the elderly in the community health management program in Nanjing was 10.6% (95%CI: 9.82%-11.38%). There were significant differences in age, gender, education level, blood pressure, marital status, alcohol consumption, as well as the levels of fasting plasma glucose (FPG), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and blood urea nitrogen (BUN) between the CKD group and the non-CKD group (all P<0.05). Univariate logistic regression analysis revealed that age ≥70 years, female, diabetes, hypertension, low HDL-C, high TG, and abnormal levels of BUN and total bilirubin (TBIL) were positively associated with the risk of CKD (all P<0.05). In contrast, higher education and regular alcohol consumption were negatively associated with the risk of CKD (all P<0.05). Multivariate logistic regression analysis indicated that age ≥70 years, female, smoking, hypertension, diabetes, high TG, low HDL-C, and abnormal levels of BUN and TBIL significantly increased the risk of CKD, while regular alcohol consumption was associated with a reduced risk. Conclusions Age, gender, hypertension, diabetes, dyslipidemia, and abnormal levels of BUN and TBIL are closely associated with the occurrence of CKD in the elderly. Measures should be taken to control blood pressure, blood glucose, blood lipids, BUN, and TBIL levels in the elderly to prevent the onset and progression of CKD.    

Key words: chronic kidney disease, dyslipidemia, influencing factor, National Essential Public Health Service