Abstract: Objective To explore the relationship of serum uric acid(SUA) level with the decline in estimated glomerular filtration rate(eGFR) and the progression of chronic kidney disease(CKD) among the elderly. Methods A cohort of elderly adults in Foshan was established. The elderly individuals aged ≥65 years old who underwent health examinations in the Seventh Affiliated Hospital of Southern Medical University from January to December 2021 were enrolled in this study. The basic data of questionnaires, physical examinations, and laboratory indicators including blood lipids, blood glucose, and liver and kidney function were collected. All cases were followed for 2 years. The correlations of SUA level with eGFR and eGFR slope were analyzed by multiple linear regression analysis. Logistic regression model was used to investigate the influencing factors of the progression of CKD stage. Results With the increase of SUA level, eGFR significantly decreased(P<0.001), and the prevalence of CKD significantly increased(P<0.001). There was no statistical correlation between baseline SUA level and eGFR slope or CKD progression during the 2-year follow-up (P>0.05),but there was a significant correlation between the change of SUA level and eGFR slope or CKD progression(P<0.001). Logistic regression analysis showed that the change of SUA level was the risk factor for CKD progression. Conclusions In the elderly adults, SUA is significantly correlated with eGFR and the prevalence of CKD. The change of SUA level is significantly correlated with the decline of eGFR and the progression of CKD. Controlling the change of SUA level can prevent the occurrence and development of CKD.

Key words: serum uric acid, estimated glomerular filtration rate, chronic kidney disease, cohort study