Abstract: Objective To investigate the relationship between triglyceride-glucose index (TyG index) and the risk of evalucated glomerular filtration rate (eGFR) in the elderly population, and to explore its value as a simple indicator of insulin resistance(IR) in predicting the risk of chronic kidney disease (CKD). Methods A total of 5946 elderly patients (mean age: 70.54 years old, male account for 63.2%) who participated in physical examination from January to December 2019 were enrolled in this study. Through cross-sectional study, multi-factor Logistic regression and stratified analysis were used to explore the correlation between TyG index and CKD, and the receiver operating characteristic (ROC) curve predicting CKD was drawn. Results In 5946 subjects aged≥ 60 years, the incidence rate of CKD was 4.6%. Multi-factor Logistic regression model showed that TyG index was a risk factor for CKD. After adjusting sex, age, hypertension and body mass index (BMI), there was still a significant correlation between elevated TyG index and the risk of CKD. ROC curve analysis showed that TyG index and the clinical factors including age, sex, obesity and hypertension had a certain value in evaluating the occurrence of CKD, and the area under the curve (AUC) was 0.579 and 0.774, respectively. Further study showed that the predictive effect of TyG index combined with clinical factors was significantly better, and the AUC was 0.791. Conclusions As a simple index, TyG index has certain value in predicting the risk of CKD in the elderly population in Nanjing.

Key words: insulin resistance, chronic kidney disease, triglyceride-glucose product index