青藤碱治疗糖尿病肾病的研究进展

doi:10.3969/j.issn.1003-9198.2025.11.019

摘要/Abstract

摘要： 糖尿病肾病作为糖尿病常见并发症,其发病机制复杂,涉及高血糖、氧化应激、炎症反应及代谢紊乱等多种因素的相互作用。近年来,传统中药成分青藤碱因其抗炎、抗氧化及免疫调节等药理特性,在多种肾脏疾病的治疗中展现出显著潜力。本研究主要就糖尿病肾病的发病机制以及青藤碱通过抗炎以及抗氧化作用治疗糖尿病肾病的具体机制进行综述,并初步探讨青藤碱的多靶点干预特性与中医药整体治疗理念相契合的前景,以期为糖尿病肾病的综合管理提供一定的辩证思路。

关键词: 青藤碱, 糖尿病肾病, 炎症反应, 氧化应激

Abstract: Diabetic kidney disease, a common complication of diabetes mellitus, is characterized by a complex pathogenesis involving the interplay of multiple factors, including hyperglycemia, oxidative stress, inflammatory responses, and metabolic disorders. In recent years, sinomenine, a traditional Chinese herbal component, has demonstrated significant potential in the treatment of various renal diseases due to its pharmacological properties of anti-inflammation, antioxidant effects, and immune regulation. This article reviews the pathogenesis of diabetic kidney disease and the specific mechanisms by which sinomenine treats diabetic kidney disease through its anti-inflammatory and antioxidant effects. Additionally, it preliminarily explores the prospects of integrating the multi-target intervention characteristics of sinomenine with the holistic treatment philosophy of traditional Chinese medicine, aiming to provide a dialectical approach for the comprehensive management of diabetic kidney disease.

Key words: sinomenine, diabetic kidney disease, inflammatory response, oxidative stress

中图分类号:

R 587.2

刘苗, 闵丹燕, 储文文, 乔诚, 詹秋楠, 赵俊丽. 青藤碱治疗糖尿病肾病的研究进展[J]. 实用老年医学, 2025, 39(11): 1169-1173.

LIU Miao, MIN Danyan, CHU Wenwen, QIAO Cheng, ZHAN Qiunan, ZHAO Junli. Research progress of the effects of sinomenine in the treatment of diabetic kidney disease[J]. Practical Geriatrics, 2025, 39(11): 1169-1173.

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