辣椒素在骨关节炎中的作用研究进展

doi:10.3969/j.issn.1003-9198.2024.02.022

摘要/Abstract

摘要： 骨关节炎(OA)是一种包含多重病理机制的、影响整个关节的复杂疾病,严重危害国民健康,并给家庭、社会带来沉重经济负担。关节软骨退变和滑膜炎是OA主要的病理表现,但目前缺少针对发病机制的精准治疗方案,临床用药还停留在非甾体类抗炎药和镇痛药阶段。研究显示,辣椒素(CPS)作为辣椒的主要活性成分,能够对OA的多重病理机制发挥治疗作用,包括缓解疼痛、抑制炎症反应和氧化应激等,在针对多种病理过程的以发病机制为基础的OA治疗中发挥临床转化潜力。因此,本综述旨在阐述CPS对OA的药理作用机制及其在骨关节领域的研究进展。

关键词: 骨关节炎, 辣椒素, 瞬时受体电位香草醛1, 疼痛, 炎症, 氧化应激

中图分类号:

R 684.3

李维彤, 谢亚, 吕中阳, 史冬泉. 辣椒素在骨关节炎中的作用研究进展[J]. 实用老年医学, 2024, 38(2): 198-202.

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