Abstract: Objective To explore the association between the serum level of 25-hydroxyvitamin D (25(OH)D)] and the muscle content of hip in the elderly men with different age, and to provide a new viewpoint for the prevention of sarcopenia. Methods The clinical data of 180 elderly men in Department of Geriatrics, Nanjing Drum Tower Hospital from January 2020 to October 2021 were retrospectively analyzed. Local muscle content of the hip and waist were measured using dual-energy X-ray absorptiometry (DXA). The data of the muscle mass ratio around the waist and hip were collected according to the local BMD model. The subjects were divided into three groups according to the age (60-69 years group,70-79 years group and ≥80 years group). The relationship between vitamin D and local muscle content was analyzed using partial correlation analysis and multiple linear regression. Results With the increase of age, there were significant decreases in muscle content of the hip and BMI (P<0.05).There were no significant differences in the serum level of 25(OH)D and the muscle content of the waist between the three groups. There was a positive correlation between the serum level of 25(OH)D and the muscle content of the hip in 60-69 years group (r=0.165, P<0.05). The results of multiple linear regression analysis showed that the serum level of 25(OH)D and waist muscle content were positively correlated with hip muscle content(B=0.069, 0.335, P<0.05), and BMI was negatively correlated with hip muscle content( B=-0.326, P<0.05). Conclusions In the elderly men aged 60-69 years old, the decrease of serum level of 25(OH)D has a significant effect on muscle content of the hip, and supplementing vitamin D is helpful to reduce the incidence of sarcopenia and osteoporosis.

Key words: elderly men, vitamin D, muscle content, correlation