老年血液透析病人衰弱与血清瘦素及25-羟维生素D的相关性研究

doi:10.3969/j.issn.1003-9198.2024.06.014

Abstract

Abstract: Objective To investigate the levels of serum leptin and 25-hydroxyvitamin D [25(OH)D], and to analyze their correlation with frailty in the elderly hemodialysis patients. Methods A total of 150 elderly hemodialysis patients admitted to our hospital from April 2021 to April 2023 were enrolled in this study. The patients were divided into non-frailty group (51 cases), pre-frailty group (74 cases) and frailty group (25 cases) according to Fried phenotype. The general data, serum leptin, 25(OH)D and cardiac function of the three groups were compared. Multivariate Logistic regression was used to analyze the influencing factors of frailty in the elderly hemodialysis patients. Results There were significant differences in age, proportion of diabetes mellitus, dialysis age, left ventricular end-diastolic diameter, albumin, magnesium, IL-6, leptin and 25(OH)D levels among the three groups (P<0.01). Multivariate Logistic regression analysis showed that age, dialysis age, diabetes, magnesium, IL-6, albumin, leptin, 25(OH)D and left ventricular end-diastolic diameter were the independent factors of frailty in the elderly hemodialysis patients (P<0.05). Conclusions It is important to intervene the low level of albumin, high level of leptin and low level of 25(OH)D to delay the progression of frailty in the elderly hemodialysis patients.

Key words: leptin, 25-hydroxyvitamin D, hemodialysis, frailty, heart function

CLC Number:

R692

ZHU Bei, HANG Lejia, GAO Fei, YUAN Haichuan, ZHAO Weihong. Correlation of frailty with serum leptin and 25-hydroxyvitamin D in elderly hemodialysis patients[J]. Practical Geriatrics, 2024, 38(6): 603-606.

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Correlation of frailty with serum leptin and 25-hydroxyvitamin D in elderly hemodialysis patients

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