转运RNA衍生片段在衰老相关疾病中的研究进展

doi:10.3969/j.issn.1003-9198.2026.03.015

Abstract

Abstract: Transfer RNA-derived fragments (tRFs), generated through specific nuclease cleavage of transfer RNAs (tRNAs), represent a class of non-coding RNAs characterized by high evolutionary conservation, structural stability, and functional diversity. Their aberrant expression has been implicated in various pathological conditions, exhibiting regulatory mechanisms that are more intricate than those of microRNAs (miRNAs), which function through multiple pathways such as miRNA-like effect, translation regulating, and interactions with RNA-binding proteins. With the global trend of population aging, dysregulated expression of tRFs in aging-related pathologies, including neoplasms, neurodegenerative disorders, and metabolic syndromes, has garnered significant scientific attention. Furthermore, the remarkable stability of tRFs in bodily fluids makes them promising candidates for non-invasive biomarkers. This review summarizes the classification of tRFs and discusses their diagnostic and therapeutic potential in age-associated diseases, aiming to provide novel perspectives for advancing research in this emerging field.

Key words: transfer RNA-derived fragments, cancer, Alzheimer’s disease, Parkinson’s disease, biomarker

CLC Number:

R 393

DE Xiaomeng. Advances of transfer RNA-derived fragments in age-related diseases[J]. Practical Geriatrics, 2026, 40(3): 299-303.

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Advances of transfer RNA-derived fragments in age-related diseases

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