单细胞转录组测序在阿尔茨海默病中的研究进展

doi:10.3969/j.issn.1003-9198.2025.08.021

Abstract

Abstract: Alzheimer’s disease (AD) is one of the prevalent neurodegenerative diseases in the elderly patients, characterized by progressive cognitive decline and the accumulation of lesioned neurons. With the aging of the population, the incidence of AD is increasing year by year, and in-depth exploration of its pathogenesis can help to identify potential predictive and therapeutic targets. Single-cell RNA sequencing (scRNA-seq) is an emerging next-generation sequencing (NGS) technology that enables high-resolution profiling of gene expression at the single cell level. This approach overcomes the inherent limitations of traditional bulk RNA sequencing, which only captures averaged transcriptional responses across heterogeneous cell populations. By dissecting cellular heterogeneity among phenotypically similar cells,scRNA-seq provides novel insights into AD pathogenesis. This paper summarizes the methodologies and applications of scRNA-seq, and describes the potential application value in unraveling the pathogenesis of AD and developing therapeutic target drugs.

Key words: Alzheimer’s disease, single-cell RNA sequencing, cellular heterogeneity, neurons

CLC Number:

R742

ZHONG Yi, FENG Yue, ZHANG Xinlong, DING Rui, SI Yanna. Research progress in single-cell RNA sequencing for Alzheimer’s disease[J]. Practical Geriatrics, 2025, 39(8): 857-861.

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Research progress in single-cell RNA sequencing for Alzheimer’s disease

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