老年T2DM病人甘油三酯葡萄糖指数与低密度脂蛋白亚型的关系研究

doi:10.3969/j.issn.1003-9198.2024.10.008

Abstract

Abstract: Objective To investigate the correlation between triglyceride-glucose (TyG) index and low-density lipoprotein (LDL) subtypes in the elderly patients with type 2 diabetes mellitus (T2DM). Methods The clinical data of 360 elderly T2DM patients admitted to Affiliated Jiangning Hospital of Nanjing Medical University from January 2022 to March 2023 were analyzed retrospectively. The correlation between TyG index and LDL subtypes was analyzed, and the cut-off value of elevated small dense low-density lipoprotein cholesterol (sdLCL-C) level was defined by receiver operating characteristic (ROC) curve analysis. Results All patients were divided into 4 groups according to the quartiles of TyG index level. The level of TyG index was positively correlated with LDL-C3, LDL-C4, LDL-C5, LDL-C6 and LDL-C7 (P<0.01), and negatively correlated with LDL-C1 and LDL-C2 (P<0.01). Logistic regression analysis showed a significant positive correlation between TyG index level and high sdLDL-C level. The cut-off value of TyG index to predict the occurrence of high sdLDL-C was 9.0, and the area under the curve was 0.70. Conclusions In the elderly patients with T2DM, TyG index is closely related to sdLDL-C level, which may be a simple and feasible clinical indicator to recognize the increase of the level of sdLDL-C.

Key words: type 2 diabetes mellitus, triglyceride-glucose index, low-density lipoprotein subtype

CLC Number:

R 587.1

WANG Su, ZHAO Yijing, WEI Chenmin, CHEN Kun, CAO Wen, WANG Kun, YANG Yu. Correlation of triglyceride-glucose index with low-density lipoprotein subtypes in elderly patients with type 2 diabetes mellitus[J]. Practical Geriatrics, 2024, 38(10): 1002-1006.

References

[1] 田思雨, 王志勇, 娄青林, 等. 南京市城区老年人群2000年和2017年糖尿病自我报告患病率情况及变化[J]. 实用老年医学, 2023, 37(6):615-619.
[2] 中国老年2型糖尿病防治临床指南编写组, 中国老年医学学会老年内分泌代谢分会, 中国老年保健医学研究会老年内分泌与代谢分会, 等. 中国老年2型糖尿病防治临床指南(2022年版)[J]. 中华内科杂志, 2022, 61(1):12-50.
[3] FROYEN E. The effects of fat consumption on low-density lipoprotein particle size in healthy individuals: a narrative review[J]. Lipids Health Dis, 2021, 20(1):86.
[4] AI M, OTOKOZAWA S, ASZTALOS B F, et al. Small dense LDL cholesterol and coronary heart disease: results from the Framingham Offspring Study[J]. Clin Chem, 2010, 56(6):967-976.
[5] WU D, YANG Q, SU B, et al. Low-density lipoprotein cholesterol 4: the notable risk factor of coronary artery disease development[J]. Front Cardiovasc Med, 2021, 8:619386.
[6] PARK S E, PARK C Y, SWEENEY G. Biomarkers of insulin sensitivity and insulin resistance: past, present and future[J]. Crit Rev Clin Lab Sci, 2015, 52(4):180-190.
[7] TAHAPARY D L, PRATISTHITA L B, FITRI N A, et al. Challenges in the diagnosis of insulin resistance: focusing on the role of HOMA-IR and tryglyceride/glucose index[J]. Diabetes Metab Syndr, 2022, 16(8):102581.
[8] SELVI N M K, NANDHINI S, SAKTHIVADIVEL V, et al. Association of triglyceride-glucose index (TyG index) with HbA1c and insulin resistance in type 2 diabetes mellitus[J]. Maedica: Bucur, 2021, 16(3):375-381.
[9] SUPERKO H, GARRETT B. Small dense LDL: scientific background, clinical relevance, and recent evidence still a risk even with ‘normal’ LDL-C Levels[J]. Biomedicines, 2022, 10(4):829.
[10] JIN X, YANG S, LU J, et al. Small, dense low-density lipoprotein-cholesterol and atherosclerosis: relationship and therapeutic strategies[J]. Front Cardiovasc Med, 2021, 8:804214.
[11] RIKHI R, SCHAICH C L, HAFZALLA G W, et al. Small dense low-density lipoprotein cholesterol and coronary artery calcification in the multi-ethnic study of atherosclerosis[J]. Eur J Prev Cardiol, 2024, 31(8):1048-1054.
[12] SCHAEFER E J, IKEZAKI H, DIFFENDERFER M R, et al. Atherosclerotic cardiovascular disease risk and small dense low-density lipoprotein cholesterol in men, women, African Americans and non-African Americans: the pooling project[J]. Atherosclerosis, 2023, 367:15-23.
[13] HUANG J, GU J X, BAO H Z, et al. Elevated serum small dense low-density lipoprotein cholesterol may increase the risk and severity of coronary heart disease and predict cardiovascular events in patients with type 2 diabetes mellitus[J]. Dis Markers, 2021, 2021:5597028.
[14] TAO L C, XU J N, WANG T T, et al. Triglyceride-glucose index as a marker in cardiovascular diseases: landscape and limitations[J]. Cardiovasc Diabetol, 2022, 21(1):68.
[15] MORA S, OTVOS J D, ROSENSON R S, et al. Lipoprotein particle size and concentration by nuclear magnetic resonance and incident type 2 diabetes in women[J]. Diabetes, 2010, 59(5):1153-1160.
[16] WEI D, MARRACHELLI V G, MELGAREJO J D, et al. Lipoprotein profiles of fat distribution and its association with insulin sensitivity[J]. Front Endocrinol: Lausanne, 2022, 13:978745.
[17] KIM S, LEE J W, LEE Y, et al. Association between triglyceride-glucose index and low-density lipoprotein particle size in Korean obese adults[J]. Lipids Health Dis, 2023, 22(1):94.
[18] RASHID S, WATANABE T, SAKAUE T, et al. Mechanisms of HDL lowering in insulin resistant, hypertriglyceridemic states: the combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity[J]. Clin Biochem, 2003, 36(6):421-429.
[19] PONT F, DUVILLARD L, FLORENTIN E, et al. Early kinetic abnormalities of apoB-containing lipoproteins in insulin-resistant women with abdominal obesity[J]. Arterioscler Thromb Vasc Biol, 2002, 22(10):1726-1732.
[20] VERGES B. Pathophysiology of diabetic dyslipidaemia: where are we?[J]. Diabetologia, 2015, 58(5):886-899.

Correlation of triglyceride-glucose index with low-density lipoprotein subtypes in elderly patients with type 2 diabetes mellitus

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