Abstract: Objective To analyze the relationship of glycosylated hemoglobin (HbA1c) level with cardiac structure and function in elderly patients with chronic heart failure and type 2 diabetes (T2DM). Methods A total of 210 elderly patients with chronic heart failure (NYHA gradeⅡ-Ⅳ)combined with T2DM were divided into two groups based on the mean value of HbA1c≤7% or ＞7%.The levels of blood lipid, cardiac structure and function were detected and compared between the two groups.And the correlation of HbA1c with blood lipid, cardiac structure and function were analyzed by Spearman correlation analysis. Results HbA1c ≤ 7% group and HbA1c>7% group showed statistical differences in interventricular septal thickness (IVS), left ventricular posterior wall thickness(LVPW), left ventricular fractional shortening rate (Fs), left ventricular ejection fraction(LVEF), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) (P<0.05). Spearman correlation analysis showed that HbA1c level was positively correlated with the levels of IVS, LVPW, TC and LDL-C(r=0.138, 0.152, 0.289, 0.290, P<0.05), and negatively correlated with the level of LVEF(r=-0.196, P<0.05). Conclusions The elderly patients with T2DM and chronic heart failure whose HbA1c level is higher than 7% have higher levels of TC and LDL-C. Controlling the level of HbA1c below 7% can effectively delay the decline of cardiac structure and function.

Key words: chronic heart failure, type 2 diabetes mellitus, glycosylated hemoglobin, cardiac structure, cardiac function