血清血管紧张素Ⅱ和一氧化氮水平与老年慢性心力衰竭病人认知功能障碍的相关性

doi:10.3969/j.issn.1003-9198.2024.02.006

Abstract

Abstract: Objective To investigate the correlation of serum angiotensin Ⅱ(AngⅡ) and nitric oxide(NO) with cognitive dysfunction in the elderly patients with chronic heart failure(CHF), and to analyze the predictive value of AngⅡ and NO for cognitive dysfunction. Methods A total of 86 elderly patients with CHF admitted to Department of Cardiology in our hospital from January 2020 to December 2022 were selected. According to the score of Montreal Cognitive Assessment Scale(MoCA), the patients were divided into cognitive dysfunction group with MoCA score <26 and normal cognitive function group with MoCA score ≥ 26. The general data of the patients were collected, and the serum levels of AngⅡand NO were detected. The correlations of the levels of serum AngⅡand NO with MoCA score were analyzed by Pearson correlation coefficient, and the influencing factors of cognitive dysfunction in elderly patients with CHF were analyzed by Logistic regression. The predictive value of serum AngⅡand NO for cognitive dysfunction in the elderly patients with CHF was analyzed by receiver operating characteristic curve. Results The proportion of education length >12 years, the levels of left ventricular ejection fraction(LVEF) and NO in the cognitive dysfunction group were lower than those in the normal cognitive function group, and the serum level of Ang Ⅱ was higher than that in the normal cognitive function group(P<0.01). Logistic regression analysis showed that LVEF and NO were the protective factors of cognitive dysfunction in the elderly patients with CHF, and AngⅡ was the risk factor. Both AngⅡ and NO had predictive value for cognitive dysfunction in the elderly patients with CHF, and the combination of the two indexes had a better predictive value with the sensitivity of 82.69% and specificity of 85.29%, respectively. Conclusions The levels of AngⅡ and NO are related to the occurrence of cognitive dysfunction in the elderly patients with CHF. The combination of AngⅡ and NO has a better predictive value for the cognitive dysfunction in the elderly patients with CHF.

Key words: chronic heart failure, cognitive dysfunction, angiotensin Ⅱ, nitric oxide

CLC Number:

R 541.6

CHENG Qing, XU Yan, CHEN Guofei, DENG Xinyue. Correlation of serum angiotensin Ⅱ and nitric oxide levels with cognitive dysfunction in elderly patients with chronic heart failure[J]. Practical Geriatrics, 2024, 38(2): 132-135.

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Correlation of serum angiotensin Ⅱ and nitric oxide levels with cognitive dysfunction in elderly patients with chronic heart failure

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