肠内营养联合双歧杆菌三联活菌对老年慢性心力衰竭病人心功能及微炎症状态的影响

doi:10.3969/j.issn.1003-9198.2022.09.005

Abstract

Abstract: Objective To explore the effect of enteral nutrition combined with Bifidobacterium triple viable on cardiac function and the levels of interleukin-1β(IL-1β), interleukin-6 (IL-6), serum amyloid A(SAA) in the elderly patients with chronic heart failure. Methods A total of 210 elderly patients with chronic heart failure in Department of Geratology of Shenzhen People's Hospital from November 2018 to May 2021 were randomly divided into the control group, the enteral nutrition group and the enteral nutrition combined with Bifidobacterium triple viable group(the combination group), with 70 cases in each group. The enteral nutrition group received basic treatment of heart failure and enteral nutrition. The combination group was treated with Bifidobacterium triple viable on the basis of the enteral nutrition group. The control group was given normal diet on the basis of the basic treatment. Four weeks later, the nutritional status indexes including albumin(ALB), prealbumin(PA), transferrin(TF), the levels of inflammatory factors including IL-1β, IL-6, SSA and cardiac function indexes including N-terminal pro-brain natriuretic peptide(NT-proBNP), ischemia-modified albumin(IMA) and left ventricular ejection fraction(LVEF) of the three groups before and after treatment were compared. Results The levels of ALB, PA, TF in the combination group after treatment were higher than those before treatment and those in the enteral nutrition group(P<0.05). The levels of ALB, PA, TF of the enteral nutrition group after treatment were higher than those before treatment and those in the control group(P<0.05). The level of LVEF in the three groups was increased after treatment(P<0.05). There was no significant difference in LVEF among the three groups after treatment (P>0.05). After treatment, the levels of IL-1β, IL-6, SSA and NT-proBNP, IMA were lowest in the combination group, followed by the enteral nutrition group and the control group(P<0.05). Conclusions Enteral nutrition combined with Bifidobacterium triple viable can improve the heart function of the elderly patients with chronic heart failure by improving the nutritional status and regulating the micro-inflammatory state.

Key words: enteral nutrition, Bifidobacterium triple viable, chronic heart failure, inflammatory factor, cardiac function

CLC Number:

R541.6

LUO Te-dan, ZHOU Chong-chong, HUANG He-ming. Effect of enteral nutrition combined with Bifidobacterium triple viable on cardiac function and microinflammation in elderly patients with chronic heart failure[J]. Practical Geriatrics, 2022, 36(9): 883-887.

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Effect of enteral nutrition combined with Bifidobacterium triple viable on cardiac function and microinflammation in elderly patients with chronic heart failure

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